血清生长激素释放肽水平对COPD患者营养状况的影响  

Effect of serum level of growth hormone releasing peptide on nutritional status of COPD patients

作　　者：李欣颖 李伟[1] 陈娟[1] 冯光球[1] 曾敏[1] LI Xinying;LI Wei;CHEN Juan;FENG Guangqiu;ZENG Min(Medical Center,Hainan Provincial People′s Hospital,Haikou,Hainan 570300,China)

机构地区：[1]海南省人民医院保健中心,海南海口570300

出　　处：《国际检验医学杂志》2020年第15期1814-1817,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金地区科学基金项目(81760054)。

摘　　要：目的探讨血清生长激素释放肽(GHRP)对慢性阻塞性肺疾病(COPD)患者营养状况的影响及临床意义。方法选取2016年6月至2018年6月海南省人民医院呼吸科收治的102例COPD患者作为研究对象,根据体质量指数(BMI)将所有患者分为低BMI组和高BMI组,每组各51例。另选取50例健康人员作为对照组。比较各组一般临床资料,包括BMI、体脂百分比、用力肺活量(FVC)和第1秒用力呼气容积(FEV1)水平,采用酶免疫测定法检测各组血清GHRP和生长激素(GH)水平,观察各组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和C反应蛋白(CRP)水平,并进行相关性分析。结果3组BMI、体脂百分比、FVC和FEV1水平比较,差异均有统计学意义(P<0.05),且低BMI组各项指标水平均低于高BMI组和对照组。3组血清GHRP、GH、TNF-α、IL-6和CRP水平差异均有统计学意义(P<0.05)。COPD患者中低BMI组GHRP水平与BMI、体脂百分比均呈负相关;GH水平与BMI呈正相关;GH与GHRP无相关性,GHRP水平与TNF-α、IL-6均呈正相关。结论血清GHRP对评估COPD患者营养状况和疾病进展有临床指导作用。Objective To explore the effect and clinical significance of growth hormone releasing peptide(GHRP)on nutritional status of chronic obstructive pulmonary disease(COPD)patients.Methods From June 2016 to June 2018,102 COPD patients admitted to the Department of Respiratory of Hainan Provincial People′s Hospital were selected.According to body mass index(BMI),all patients were divided into low BMI group and high BMI group,with 51 patients in each group.Another 50 healthy persons were selected as the control group.The general clinical data of each group were compared,including BMI,body fat percentage,forced vital capacity(FVC)and forced expiratory volume in the first second(FEV1).The serum levels of GHRP and growth hormone(GH)in different groups were measured by Enzyme Immunoassay.Serum levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)were observed,and then the correlations of all the data were analyzed.Results The differences of BMI,body fat percentage,FVC and FEV1 index levels in the three groups were statistically significant(P<0.05),and all indexes in the low BMI group were higher than those of the high BMI group and the control group.There were significant differences in GHRP,GH,TNF-α,IL-6 and CRP levels between three groups(P<0.05).There was a negative correlation between the level of GHRP and BMI and body fat percentage in the low BMI group.GH level was positively correlated with BMI.There was no correlation between GH and GHRP,but there was a positive correlation between GHRP and TNF-α,IL-6.Conclusion GHRP may play a clinical role in the assessment of nutritional status and disease progression of COPD patients.

关 键 词：慢性阻塞性肺疾病 生长激素释放肽 生长激素 内分泌调节 

分 类 号：R563.9[医药卫生—呼吸系统]