2013-2018年太原市手足口病病原监测结果分析  

Analysis of pathogen detection results of hand, foot and mouth disease in Taiyuan between 2013 and 2018

作　　者：柴向琪 王骥涛[2] 高瑞红[2] 师浩桐 张伟虹 姚红[1] CHAI Xiang-qi;WANG Ji-tao;GAO Rui-hong;SHI Hao-tong;ZHANG Wei-hong;YAO Hong(Department of Microbiology and Immunology,Shanxi Medical University,Taiyuan,Shanxi 030001,China;不详)

机构地区：[1]山西医科大学微生物学与免疫学教研室,山西太原030001 [2]太原市疾病预防控制中心,山西太原030001

出　　处：《现代预防医学》2020年第14期2628-2630,2647,共4页Modern Preventive Medicine

基　　金：山西省卫生厅科学技术攻关项目(201302026)。

摘　　要：目的对2013-2018年太原市手足口病患者咽拭子标本进行病原学分析,为太原市手足口病预防提供科学依据。方法收集手足口病患者咽拭子标本3 621份,采用荧光定量逆转录-聚合酶链式反应检测病毒核酸进行肠道病毒分型,采用Excel 2003进行数据整理,用SPSS Statistics 22.0对样本阳性率进行χ2检验。结果肠道病毒(HEV)阳性标本2 387份,阳性率66.89%,分为EV71、CVA16和其他肠道病毒,阳性率分别为13.53%、23.12%和30.24%;2013-2018年的HEV阳性率总体呈逐年下降的趋势(χ2=97.996,P<0.001);5-7月份阳性标本数最多,占全年的76.42%;男女性阳性率无差异(χ2=3.647,P=0.056),1~5岁年龄组阳性标本数最多,占比84.89%;阳性率排在前3位的县区是清徐县、杏花岭区和阳曲县较高,分别为80.10%(310/387)、76.49%(244/319)和75.36%(156/207)。结论太原市手足口病病原体型别分布呈现时间差异,人群差异及地区差异,应针对性提出预防措施,并扩大肠道病毒监测范围。Objective To analyze the pathogens of throat swab specimens from patients with hand, foot and mouth disease in Taiyuan from 2013 to 2018, and provide scientific evidence for prevention of hand, foot and mouth disease in Taiyuan.Methods A total of 3621 samples of throat swabs from patients with hand, foot and mouth disease were collected. Viral nucleic acid was detected by fluorescence quantitative reverse transcription-polymerase chain reaction for enterovirus typing.Results 2387 cases of enterovirus(HEV) positive samples(the positive rate was 66.89%) were divided into EV71, CVA16 and other enteroviruses, and the positive rates were 13.53%, 23.12% and 30.24%, respectively. The number of positive specimens was the highest in May-July, accounting for 76.42% of the whole year. The overall positive rate of HEV in 2013-2018 showed a downward trend year by year(χ2=97.996, P <0.001). There was no difference between positive rate of male and female(χ2=3.647, P=0.056). The number of positive specimens in the 1-5 age group was the highest, accounting for 84.89%.The counties with the highest positive rate are Qingxu County, Xinghualing District and Yangqu County, 80.10%(310/387),76.49%(244/319), and 75.36%(156/207), respectively. Conclusion The distribution of pathogen types in hand-foot-and-mouth disease in Taiyuan shows time difference, population difference and regional difference. Precautionary measures should be proposed and the scope of intestinal virus surveillance should be expanded.

关 键 词：手足口病 肠道病毒 病原学 

分 类 号：R115[医药卫生—公共卫生与预防医学]