贵州省侗族人群铅暴露水平与糖尿病前期、糖尿病的关联性初探  

The correlation between lead exposure level and the prevalence of diabetes and prediabetes among Dong minority in Guizhou Province

作　　者：张均涛 唐学杰 雷娟[3] 刘磊磊 詹少辉 覃子秀 金照凤 张才良 刘雅兰 尹朝晖 洪峰 ZHANG Jun-tao;TANG Xue-jie;LEI Juan;LIU Lei-lei;ZHAN Shao-hui;QIN Zi-xiu;JIN Zhao-feng;ZHANG Cai-liang;LIU Ya-lan;YIN Chao-hui;HONG Feng(School of Public Health,the Key Laboratory of Environ-mental Pollution Monitoring and Disease Control,Ministry of Education,Guizhou Medical University,Guiyang,Guizhou 550025,China;不详)

机构地区：[1]贵州医科大学公共卫生学院,环境污染与疾病监控教育部重点实验室,贵州贵阳550025 [2]贵州医科大学大学城医院,贵州贵阳550025 [3]贵阳市疾病预防控制中心,贵阳550003 [4]贵州医科大学第二附属医院,贵州凯里556000

出　　处：《现代预防医学》2020年第14期2648-2651,2676,共5页Modern Preventive Medicine

基　　金：贵州省苗族、侗族、布依族世居自然人群环境暴露与健康风险的前瞻性队列研究(黔科合平台人才[2018]5403)。

摘　　要：目的探讨侗族人群铅暴露与糖尿病前期、糖尿病的关联性。方法通过分层多阶段抽样调查贵州省侗族30~79岁之间的居民共3225人,采用问卷调查、体格检查采集居民健康状况并收集生物样本,电感耦合等离子体质谱法来检测调查对象尿铅浓度,采用非条件logistic回归分析尿铅(四分位数)与糖尿病前期、糖尿病患病风险的关联性。结果贵州省侗族人群尿铅浓度为2.87μg(1.33~4.83μg),糖尿病患病率为9.02%(291/3225人),糖尿病前期患病率为48.00%(1548/3225人),多因素校正后,尿铅浓度与糖尿病前期存在关联,尿铅浓度的第四分位与第一分位相比OR=1.41(1.15,1.72),未发现尿铅浓度与糖尿病之间有明显关联性。结论贵州省侗族人群中尿铅浓度的升高与糖尿病前期风险具有关联性,未发现尿铅浓度与糖尿病患病风险存在关联性。Objective To investigate the association of lead exposure with the prevalence of prediabetes and diabetes among Dong minority in Guizhou Province. Methods Through multi-stage stratified sampling survey, a total of 3225 males and females aged 30-79 years old in Dong people in southeastern province were surveyed with a questionnaire interview, physical examination, and laboratory tests. Urinary lead levels was assessed by inductively coupled plasma mass spectrometry(ICPMS). The prevalence of diabetes and prediabetes were compared across urinary lead quartiles. Results The median concentration of urinary lead was 2.87 μg/L(interquartile range: 1.33-4.83 μg/L). The prevalence of diabetes was 9.02%(291/3225) and the prevalence of diabetes was 48.00%(1548/3225). Elevated levels of urinary lead was associated with prediabetes(P<0.001) The odds ratios(95% confidence interval) for prediabetes in the third quartile was 1.409(1.153, 1.722),respectively(referencing to 1.00). Total population found no significant correlation between urinary lead and diabetes.Conclusion Increased urinary lead concentration is associated with elevated prevalence of prediabetes and no find significant correlation between urinary lead and diabetes.

关 键 词：侗族 铅 糖尿病前期 糖尿病 关联分析 

分 类 号：R114[医药卫生—卫生毒理学]