胎膜早破孕妇衣原体和支原体感染特征、耐药性分析  

Analysis of the infection characteristics and drug resistance of Chlamydia and Mycoplasma in pregnant women with premature rupture of the membranes

作　　者：李俊强 杨鸿[1] 杨欢 许鑫玥 王莉[1] LI Jun-qiang;YANG Hong;YANG Huan;XU Xin-yue(Obstetrics and Gynecology Chengdu Third People's Hospitals Sichuan,Chengdu,China 610031)

机构地区：[1]成都市第三人民医院妇产科,四川成都610031

出　　处：《中国病原生物学杂志》2020年第6期723-725,共3页Journal of Pathogen Biology

摘　　要：目的检测胎膜早破(PROM)孕妇衣原体和支原体感染特征及其耐药性。方法选择2017年1月-2019年8月本院妇产科收治的PROM孕妇256例,正常分娩孕妇50例(为健康对照),检测衣原体和支原体感染情况,分析PROM孕妇感染衣原体和支原体的病原学特征;对分离的病原体做药敏试验,检测其对常用抗生素的耐药性。结果 256例PROM患者中沙眼衣原体(CT)和解脲支原体(UU)感染80例,感染率为31.25%。其中单一UU感染56例(占70.00%),单一CT感染7例(占8.75%),UU+CT感染8例(占10.00%)。PROM孕妇UU感染率为26.95%(69/256),CT感染率为6.25%(16/256);正常分娩孕妇UU、CT感染率分别为12.00%(6/50)和6.00%(3/50)。两组比较UU感染率差异有统计学意义(x^2=5.055,P=0.025)。UU对米诺环素、多西霉素的耐药率为0,对四环素、交沙霉素的耐药率均<30.0%;CT对多西环素的耐药率为0,对米诺环素、交沙霉素、四环素的耐药率均<30.0%;CT+UU对米诺环素、多西霉素的耐药率为25.0%。结论 PROM孕妇UU、CT感染率较高,以单一UU感染多见。UU对米诺环素和多西霉素敏感,CT对多西环素敏感,可为临床提供参考。Objectives To determine the characteristics of Chlamydia and Mycoplasma infections and their drug resistance in pregnant women with premature rupture of the membranes. Methods Subjects were 256 pregnant women with PROM seen from January 2017 to August 2019;50 pregnant women with a normal delivery served as healthy controls. A cotton swab was used to collect amniotic fluid from pregnant women or secretions were collected about 2 cm from the opening of the uterus to culture and detect Mycoplasma and Chlamydia. The pathogenic characteristics of chlamydia and mycoplasmosis in pregnant women with PROM were analyzed. A drug sensitivity test was performed on the isolated pathogens to detect their resistance to common antibiotics. From January 2017 to August 2019, 256 pregnant women with premature rupture of the membranes(PROM) were admitted to Gynecology and Obstetrics at this Hospital. Pathogens were detected in pregnant women, and the etiological characteristics of pregnant women with PROM were analyzed. Fifty normal pregnant women in the same period served as the healthy control group. The status of infection with Chlamydia trachomatis and Ureaplasma urealyticum was compared in pregnant women with PROM and normal pregnant women. The drug resistance of those pathogens was discussed. Results Of 256 patients with PROM, 31.25%(80/256) tested positive for pathogens. Of those that tested positive, 86.25%(69/80) were infected with U. urealyticum and 20.00%(16/80) were infected with C. trachomatis;56(70.00%) were infected with U. urealyticum alone, 7(8.75%) were infected with C. trachomatis alone, and 8(10.00%) were infected with U. urealyticum and C. trachomatis. Pregnant women with PROM tested positive for U. urealyticum and C. trachomatis at a significantly higher rate than did pregnant women with a normal delivery(x^2=5.055,P=0.025). There was no significant difference in the rate of infection with C. trachomatis(x^2correction=0.000, P=1.000). The resistance of U. urealyticum to minocycline and doxycycline was very low(0

关 键 词：胎膜早破 沙眼衣原体 解脲支原体 耐药性 

分 类 号：R378[医药卫生—病原生物学]