血清LDH和α-HBDH在B-ALL患者中的水平及临床意义  被引量:11

The clinical significance of serum expression level of LDH andα-HBDH in B-ALL

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作  者:许德英[1] 王小利[1] 孙真真[1] 吴玉丹[1] 常永超[1] XU De-ying;WANG Xiao-li;SUN Zhen-zhen(Department of Clinical Laboratory Diagnosis,School of Clinical Medicine,The First Affiliated Hospital of Henan Universily of Science and Technology,Luoyang 471003,China)

机构地区:[1]河南科技大学第一附属医院检验科,河南科技大学临床医学院,河南洛阳471003

出  处:《中国实验诊断学》2020年第6期930-933,共4页Chinese Journal of Laboratory Diagnosis

摘  要:目的检测血清LDH和α-HBDH在急性B淋巴母细胞白血病(B-ALL)患者中的表达水平以及探讨对疾病进展的辅助诊断意义。方法回顾性分析2018年1月-2019年5月期间我院确诊的236例B-ALL患者的临床资料及免疫分型结果。结果 236例B-ALL患者中,Pro-B以>15岁的女性为主,而Common-B和Pre-B则均以≤15岁的男性为主;与正常人群比较,LDH和α-HBDH血清检测水平在B-ALL患者中均增高(713.10±52.44U/L、485.80±35.74U/L),而且具有统计学意义(P<0.01);年龄和性别因素对B-ALL患者血清中LDH和α-HBDH水平则无影响(P>0.05)。结论通过检测B-ALL患者的血清LDH与α-HBDH水平,有助于判断疾病恶性程度,对临床诊断有一定借鉴意义。Objective Measured the expression levels of serum LDH andα-HBDH levels in patients with acute Blymphoblastic leukemia(B-ALL)and discussed their diagnostic significance.Methods Analyzed the clinical data and immunotyping results of 236 patients with B-ALL which diagnosed in our hospital from January 2018 to May 2019 retrospectively.Results Out of the 236 cases with B-ALL,Pro-B was dominated by female and aged>15 years old,while common-B and pre-B were dominated by male and aged≤15 years old.Compared with the normal population,LDH andα-HBDH levels were significantly higher in B-ALL(713.10±52.44 U/L,485.80±35.74 U/L)(P<0.01).Age and gender had no effect on serum LDH andα-HBDH levels in B-ALL(P>0.05).Conclusion Combined detection of serum LDH andα-HBDH levels in B-ALL patients could help determine the degree of malignancy of the disease,and provided early intervention for patients,which had certain reference significance for clinical diagnosis.

关 键 词:血清LDH 血清α-HBDH 急性B淋巴母细胞白血病 辅助诊断 

分 类 号:R446.112[医药卫生—诊断学]

 

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