苗药加九留对骨折愈合的修复作用  

Effect of Miao Medicine Jiajiuliu on Fracture Healing and Soft Tissue Injury

作　　者：陈常荣[1] 魏学军[1] 赵鸿宾[1] 王恒[1] 许键炜 Chen Changrong;Wei Xuejun;Zhao Hongbin;Wang Heng;Xu Jianwei(Qiannan Medical College For Nationalities,Duyun 558013,China;Department of Pharmacology,School of Basic Medicine,Guizhou Medical University,Guiyang 550004,China;Center for Tissue Engineering and Stem Cell Research,Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]黔南民族医学高等专科学校,贵州都匀558013 [2]贵州医科大学基础医学院药理学教研室,贵州贵阳550004 [3]贵州医科大学组织工程与干细胞实验中心,贵州贵阳550004

出　　处：《亚太传统医药》2020年第7期28-30,共3页Asia-Pacific Traditional Medicine

基　　金：贵州省卫生厅黔南民族医学高等专科学校科技联合基金(gzwkj2013-2-004);贵州省中医药管理局中医药、民族医药科学技术研究项目(QZYY-2016-060);贵州省科技厅联合基金项目(黔科合LH字[2015]7325)。

摘　　要：目的:探讨苗药加九留对骨折愈合及软组织损伤后的修复效果。方法:选取100只SD大鼠,随机将其分为苗药加九留高剂量组、苗药加九留低剂量组、模型组、假手术组,各25只,比较采用不同方法治疗后四组大鼠的骨折愈合效果和组织损伤修复效果。结果:苗药加九留可以提高实验性大鼠骨折的X线评分,其评分明显高于模型组(P<0.05);苗药加九留高剂量组、苗药加九留低剂量组大鼠治疗后BMP-7表达A值明显高于模型组(P<0.05);给予苗药加九留治疗28d后,大鼠骨折愈合组织的抗折断力明显高于模型组(P<0.05);苗药加九留显著提高大鼠血清bFGF和TGFβ1的含量(P<0.05)。结论:苗药加九留可以促进大鼠骨折愈合,可能是通过提高BMP-7、bFGF、TGF-β的表达促进骨折愈合。Objective:To investigate the effect of Miao Medicine Jiajiuliu on fracture healing and soft tissue injury.Methods:100 SD rats were randomly divided into the high-dose group with Miao Medicine Jiajiuliu,the low-dose group with Miao Medicine Jiajiuliu,the model group and the sham operation group,each with 25 cases,and the fracture healing effect and tissue injury repair effect of the 4 groups treated with different methods were compared.Results:the X-ray score of experimental fracture in rats was significantly higher than that of the model group(P<0.05).After treatment,bmp-7 expression A value in the high-dose group and the lowdose group was significantly higher than that in the model group(P<0.05).After 28 days of treatment with Miao Medicine Jiajiuliu,the fracture healing tissue of the rats showed significantly higher fracture resistance than that of the model group(P<0.05).The content of bFGF and TGF 1 in serum was significantly increased by the addition of the Miao Medicine Jiajiuliu(P<0.05).Conclusion:the combination of Miao Medicine Jiajiuliu can promote the fracture healing in rats,possibly by improving the expression of bmp-7,bFGF and TGF-β.

关 键 词：苗药加九留 骨折 愈合 软组织损伤 

分 类 号：R274.1[医药卫生—中医骨伤科学]