中药补阳还五汤辅助牛痘疫苗致炎兔皮提取物治疗腰椎管狭窄的研究  

A Study on the Treatment of Lumbar Spinal Stenosis with the Extract of Rabbit Skin Induced by Vaccinia Vaccine Adjuvant Buyang Huanwu Decoction

作　　者：李起明 张俊琦 石苏英 张宪林 LI Qi-ming;ZHANG Jun-qi;SHI Su-ying;ZHANG Xian-lin(Orthopedic Surgery,Shahe City Hospital of Traditional Chinese Medicine,Xingtai Hebei 054000)

机构地区：[1]邢台市沙河市中医院骨外科,河北邢台054000

出　　处：《世界中西医结合杂志》2020年第7期1358-1361,共4页World Journal of Integrated Traditional and Western Medicine

摘　　要：目的探究中药补阳还五汤辅助牛痘疫苗致炎兔皮提取物治疗腰椎管狭窄的效果。方法选取2015年12月—2017年12月期间治疗的158例腰椎管狭窄患者,采用随机数表法将其随机均分为治疗组和对照组各79例。对照组采用牛痘疫苗致炎兔皮提取物进行治疗,治疗组患者采用补阳还五汤辅助牛痘疫苗致炎兔皮提取物进行治疗。治疗1周后,比较两组患者治疗前后白介素6(IL-6)、肿瘤坏死因子-α(TNF-α)的含量变化,对两组患者的临床疗效进行比较分析,观察并记录两组患者治疗前后视觉模拟评分法(VAS)和日本骨科协会评估治疗分数(JOA)评分情况,对两组患者治疗后的疼痛时间,步行距离和治疗阶段并发症的发生情况进行比较。结果治疗后,治疗组患者的临床疗效有效率86.07%(68/79)明显高于对照组51.89%(41/79),两组比较差异有统计学意义(P<0.05)。治疗后两组腰椎管狭窄患者血清中IL-6和TNF-α的含量均低于治疗前(P<0.05),且治疗组患者血清中IL-6和TNF-α的含量均低于对照组,差异有统计学意义(P<0.05)。治疗后两组腰椎管狭窄患者的VAS评分均低于治疗前、JOA评分均高于治疗前(P<0.05),且治疗组患者的VAS评分低于对照组,JOA评分高于对照组,差异有统计学意义(P<0.05)。治疗后两组患者的疼痛时间均低于治疗前、步行距离均高于治疗前(P<0.05),且治疗组患者的疼痛时间低于对照组,步行距离高于对照组,差异有统计学意义(P<0.05)。治疗组患者的并发症发生率为7.59%,明显低于对照组的20.25%,差异有统计学意义(P<0.05)。结论补阳还五汤辅助牛痘疫苗致炎兔皮提取物对腰椎管狭窄进行治疗能明显提高治疗效果,疼痛改善效果良好,并发症发生率较低,值得广泛推广应用。Objective To explore the effect of Chinese herbal medicine BuyangHuanwu Decoction assisted with vaccinia rabbit skin extract on the treatment of lumbar spinal stenosis.Methods A total of 158 patients with lumbar spinal stenosis treated from December 2015 to December 2017 were selected and randomly divided into a treatment group and a control group with 79 cases each group.The control group was treated with vaccinia rabbit skin extract induced by vaccinia vaccine,and the treatment group was treated with BuyangHuanwu Decoction assisted vaccinia rabbit skin extract.After 1 week of treatment,before and after treatment of interleukin 6(IL-6),tumor necrosis factor alpha(TNF-α)content changes of the two groups were compared.The clinical curative effect of two groups of patients were compared and analyzed.The visual analogue scale(VAS)and Japan(Department of orthopedics Association evaluation scores JOA)scores were observed and recorded.The two groups of patients with treatment of pain after time was compared walking distance and stages of treatment complications.Results After treatment,the clinical efficacy of the observation group effective rate 86.07%(68/79)was significantly higher than that in the control group 51.89%(41/79),the difference between the two groups was statistically significant(P<0.05).After treatment,the levels of IL-6 and TNF-αin the serum of patients with lumbar spinal stenosis were lower than before treatment(P<0.05),and the levels of IL-6 and TNF-αin the patients of the treatment group were lower than those of the control.The difference was statistically significant(P<0.05).After treatment,the VAS scores of the two groups of patients with lumbar spinal stenosis were lower than before treatment,and the JOA score was higher than before treatment(P<0.05),and the VAS score of the treatment group was lower than the control group,and the JOA score was higher than the control group,the difference is statistically significant(P<0.05).After treatment,the pain time of both groups was lower than before tre

关 键 词：腰椎管狭窄 牛痘疫苗 补阳还五汤 

分 类 号：R681[医药卫生—骨科学]