激光剥蚀电感耦合等离子体质谱在生物样品定量分析中的研究进展  

Recent Advances in Quantitative Analysis of Biological Samples by Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry

作　　者：刘金辉 郑令娜[1] 汪冰[1] 陈明丽 王萌[1] 丰伟悦[1] LIU Jinhui;ZHENG Lingna;WANG Bing;CHEN Mingli;WANG Meng;FENG Weiyue(Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049;College of Sciences,Northeastern University,Shenyang 110819)

机构地区：[1]中国科学院高能物理研究所,中科院纳米生物效应与安全性重点实验室,北京100049 [2]东北大学理学院,辽宁沈阳110819

出　　处：《分析科学学报》2020年第3期443-448,共6页Journal of Analytical Science

基　　金：国家自然科学基金(Nos.U1432241,11505194,11575209);国家重点研发计划(No.2016YFA0201604)。

摘　　要：激光剥蚀-电感耦合等离子体质谱(LA-ICP-MS)作为一种可以直接分析固体材料的元素含量和同位素比值的分析技术,已经历了30多年的迅速发展。本文首先简要介绍了LA-ICP-MS的仪器装置,之后阐述了LA-ICP-MS定量分析中的基体效应、分馏效应以及定量校正方法,重点介绍了其在生物医学研究中的应用。最后对LA-ICP-MS的发展方向和应用前景进行了展望。As one of in-situ techniques for elemental and isotopic analysis,laser ablation-inductively coupled plasma-mass spectrometry(LA-ICP-MS)has been already developed for more than 30 years and been widely used in multi-disciplinary research.In this review,LA-ICP-MS system is first described briefly.Then matrix effects,fractionation effects,and quantitative strategies in LA-ICP-MS analysis are discussed,focusing on LA-ICP-MS biomedical applications.Finally,the future trend of LA-ICP-MS in biomedical research is prospected.

关 键 词：LA-ICP-MS 基体效应 分馏效应 定量分析 生物医学应用 

分 类 号：O657.63[理学—分析化学]