血清抵抗素水平与2型糖尿病大血管病变的相关性  

Correlation between serum resistin levels and macroangiopathy in patients with type 2 diabetes

作　　者：孙祯 李希圣[2] 苏淇琛[3] 董学峰 吴棋阳 Sun Zhen;Li Xisheng;Su Qichen;Dong Xuefeng;Wu Qiyang(Quanzhou Medical College,Quanzhou 362000,Fujian,China;Department of Endocrinology,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian,China;Department of Ultrasound Medicine,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian,China;Department of Clinical Laboratory,The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,Fujian,China)

机构地区：[1]泉州医学高等专科学校,福建泉州362000 [2]福建医科大学附属第二医院内分泌科,福建泉州362000 [3]福建医科大学附属第二医院超声医学科,福建泉州362000 [4]福建医科大学附属第二医院检验科,福建泉州362000

出　　处：《右江民族医学院学报》2020年第4期442-445,共4页Journal of Youjiang Medical University for Nationalities

基　　金：泉州医学高等专科学校校级科研课题(XJ1421A)。

摘　　要：目的探讨血清抵抗素(Resistin)水平与2型糖尿病患者大血管病变的相关性。方法选择55例正常对照者、50例单纯2型糖尿病患者、52例2型糖尿病合并大血管病变患者,测量其基本情况,即血压、体重、身高、腰围、臀围,计算体重指数、腰臀比。测定血脂、空腹血糖、空腹血胰岛素,计算胰岛素抵抗指数(HOMA-IR),测定血清Resistin水平并对血清Resistin水平与2型糖尿病大血管病变的相关性进行分析。结果①2型糖尿病组与2型糖尿病合并大血管病变组Resistin、HOMA-IR均高于正常对照组(P<0.05);②2型糖尿病合并大血管病变组Resistin、HOMA-IR高于2型糖尿病组(P<0.05)。结论血清Resistin水平与2型糖尿病大血管病变的发生有关。Objective To investigate the correlation between serum resistin levels and macroangiopathy in patients with type 2 diabetes.Methods Fifty-five normal controls,50 patients with type 2 diabetes alone and 52 patients with type 2 diabetes combined with macroangiopathy were selected.Their basic information,namely blood pressure,weight,height,waist circumference and hip circumference were measured,and their body mass index and waist-hip ratio were calculated.Their blood lipids,fasting blood glucose,fasting blood insulin were also measured.After the insulin resistance index(HOMA-IR)was calculated and the serum resistin level was measured,the correlation between the serum resistin level and macroangiopathy in patients with type 2 diabetes was analyzed.Results①The resistin and HOMA-IR in the type 2 diabetes group and the type 2 diabetes combined with macroangiopathy group were higher than those of the normal control group(P<0.05).②Resistin and HOMA-IR in the type 2 diabetes combined with macroangiopathy group were significantly higher than those in the type 2 diabetes group(P<0.05).Conclusion Serum resistin levels are associated with the development of macroangiopathy in patients with type 2 diabetes.

关 键 词：抵抗素 糖尿病 2型 高血压 动脉粥样硬化 

分 类 号：R587.1[医药卫生—内分泌]