柚皮素对于急性放射性皮炎的影响  

The influence of naringenin on acute radiation-induced skin reaction

作　　者：张倩玉 许斌[2] 金伟[1] 周守兵 李文娟[1] 张秋君 胡丹丹 李文玉 刘虎[1] ZHANG Qian-yu;XU Bin;JIN Wei;ZHOU Shou-bin;LI Wen-juan;ZHANG Qiu-jun;HU Dan-dan;LI Wen-yu;LIU Hu(Department of Oncology,West District of the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230000;Department of Oncology I,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]中国科学技术大学附属第一医院西区肿瘤科(安徽省肿瘤医院),合肥230000 [2]武汉大学人民医院肿瘤一科,武汉430060

出　　处：《生物学杂志》2020年第4期79-84,共6页Journal of Biology

基　　金：武汉大学医学部创新种子基金培育项目(TFZZ2018025)。

摘　　要：急性放射性皮炎是放射治疗中常见的并发症,尚无标准有效的疗法。柚皮素是一种富含于水果中的黄酮类化合物。为了探讨柚皮素对急性放射性皮炎的疗效及相关机制,40只大鼠随机分成即预防性外用组、治疗性外用组、照射后口服组、模型组和空白对照组。记录每只动物的皮炎评分。检测血清IL-6与MCP-1水平,镜下观察放疗局部皮肤组织中表真皮组织,并检测局部巨噬细胞表达。为进一步探索柚皮素对于放疗患者是否具有保护作用,纳入11例因头颈部肿瘤行双侧颈部放疗的患者,于放疗前涂抹一侧柚皮素乳膏,另一侧作为对照。结果显示,使用柚皮素可显著降低大鼠放射性皮炎的严重程度,降低外周血中IL-6与MCP-1的浓度和局部巨噬细胞浸润,改善放疗所致的表皮及真皮结构组织紊乱。11例患者中2人用药侧皮炎程度好于对照。因此,研究表明柚皮素可通过降低巨噬细胞浸润及炎症因子水平来改善大鼠放射性皮炎,尽管在人体中有效性欠佳,但安全性良好。Acute radiation-induced skin reaction is a common complication during radiation therapy and no standard and effective therapy is available currently.Naringenin is a flavonoid compound rich in fruits.In order to evaluate whether naringenin ameliorates acute radiation skin dermatitis and relative mechanism,forty male rats were divided into 5 groups randomly,including external naringenin scream prophylactically group,external naringenin cream therapeutically group,intragastrical naringenin group,irradiation model group and control group.The cutaneous damage to the rats was assessed after irradiation,the serum IL-6 and MCP-1 of the rats were also detected,the pathological change of skin structure under microscope was observed,and the local macrophage expression was analyzed.To further explore whether naringenin has a protective effect on patients suffering from radiation,eleven patients with bilateral neck radiotherapy due to head and neck tumors were enrolled.Before radiotherapy,one side was applied naringenin cream and the other side was used as a control.The results showed that the use of naringenin significantly reduced the severity of radiation dermatitis in rats,reduced the concentration of serum IL-6 and MCP-1 and local macrophage infiltration,and improved the epidermal and dermal structural disorders caused by radiotherapy.Among the 11 patients,2 patients had better dermatitis on the medication side than the control side.Therefore,this study showed that naringenin could improve radiation dermatitis in rats by reducing macrophage infiltration and inflammatory factor levels.Although the effectiveness is limite,it is safe clinically.

关 键 词：柚皮素 急性放射性皮炎 巨噬细胞 IL-6 

分 类 号：R473.73[医药卫生—护理学]