非诺贝特/介孔二氧化硅的制备及缓释性能研究  

Preparation and sustained release properties of Fenofibrate/mesoporous silica

作　　者：魏亚青 吕江维[1] 任君刚[1] 张文君[1] 王立[1] 王鹏光 WEI Ya-qing;LV Jiang-wei;REN Jun-gang;ZHANG Wen-jun;WANG Li;WANG Peng-guang(School of Pharmacy,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076

出　　处：《应用化工》2020年第7期1687-1692,共6页Applied Chemical Industry

基　　金：国家自然科学基金项目(51308171)。

摘　　要：采用单模板剂P123在强酸条件下合成具有二维六方相的SBA-15,采用双模板剂P123和F127在强酸条件下合成具有三维立方相的SBA-16。采用共沉淀法将非诺贝特负载于两种载体上,并通过扫描电镜(SEM)、高分辨透射电镜(HRTEM)、傅里叶红外光谱(FTIR)、X射线衍射(XRD)、N2吸附-脱附的材料表征方法对载药前后载体材料的性质进行研究。结果表明,SBA-15和SBA-16孔径分别为5.77 nm和3.95 nm,比表面积分别为690.19 m^2/g和807.02 m^2/g,载药量分别为32%和15%,载药后介孔材料的平均孔径、孔容及比表面积都有所降低。在不同pH溶出介质中,SBA-15和SBA-16两种介孔硅材料均起到一定缓释效果,酸性条件中,SBA-16缓释性能高于SBA-15,碱性条件下,两种材料缓释性能相近。SBA-15 with two-dimensional hexagonal phase is synthesized with single template P123 under strong acid condition,and SBA-16 with three-dimensional cubic phase is synthesized with double template P123 and F127 under strong acid condition.Fenofibrateis loaded on the two carriers by coprecipitation method.The properties of carrier materials before and after loading are studied by means of scanning electron microscopy(SEM),high resolution transmission electron microscopy(HRTEM),Fourier transform infrared spectroscopy(FTIR),X-ray diffraction(XRD)and N 2 adsorption-desorption methods.The results show that the pore sizes of SBA-15 and SBA-16 are 5.77 nm and 3.95 nm,the specific surface area is 690.19 m^2/g and 807.02 m^2/g,respectively,and the drug loadings are 32%and 15%,respectively.The average pore size,pore volume and specific surface area of the mesoporous materials decrease after drug loading.It is found that both SBA-15 and SBA-16 mesoporous silica materials have a certain sustained release effect in different pH dissolution media.The sustain release performance of SBA-16 in acidic condition is higher than that of SBA-15,and the sustain release performance of SBA-16 in alkaline condition is similar.

关 键 词：介孔二氧化硅 非诺贝特 SBA-15 SBA-16 缓释 

分 类 号：TQ469[化学工程—制药化工] R94[医药卫生—药剂学]