火针联合5-氨基酮戊酸光动力治疗面部难治性扁平疣疗效观察  

Clinical efficacy of the fire-needle therapy combined with the 5-aminolevulinic acid photodynamic therapy in the treatment of refractory flat warts on the face

作　　者：周双琳 王聪敏 王昱惠 吴英英 祝贺 ZHOU Shuang-lin;WANG Cong-min;WANG Yu-hui(Institute of Damage and Repair,the Seventh Medical Center of PLA General Hospital,Beijing 100700,China)

机构地区：[1]中国人民解放军总医院第七医学中心全军皮肤损伤修复研究所,北京100700

出　　处：《实用皮肤病学杂志》2020年第3期153-156,共4页Journal of Practical Dermatology

摘　　要：目的观察火针联合5-氨基酮戊酸光动力治疗面部难治性扁平疣临床疗效。方法符合面部难治性扁平疣诊断的患者90例,随机分为A、B、C 3组,每组30例。A组采用火针治疗,B组采用5-氨基酮戊酸光动力治疗,C组采用火针联合5-氨基酮戊酸光动力治疗。比较3组患者治疗前后皮损评分及临床有效率。随访1年,统计复发率。结果治疗前皮损评分A组(6.25±2.06)分,B组(6.21±2.13)分,C组(6.23±2.09)分,治疗后皮损评分为A组(3.17±0.93)分,B组(3.10±1.07)分,C组(1.92±0.81)分。3组治疗后皮损评分与治疗前相比,差异均有统计学意义(P<0.05);治疗后C组评分与A、B组比较,差异均有统计学意义(P<0.05)。A、B、C 3组有效率分别为76.7%、73.3%和90.0%。C组与A、B两组比较,差异均有统计学意义(P<0.05)。A、B、C3组复发率分别为30.4%、31.8%和11.1%。C与其他两组比较,差异有统计学意义(P<0.05)。结论火针联合5-氨基酮戊酸光动力治疗颜面部难治性扁平疣具有安全有效、复发率小的临床效果。Objective To observe the clinical efficacy of fire-needle therapy combined with 5-aminolevulinic acid photodynamic on treating refractory flat warts on the face.Methods 90 patients with refractory flat warts on the face were randomly divided into group A,group B and group C,30 cases in each group.Group A was treated by fire acupuncture,group B by 5-aminolevulinic acid photodynamic therapy,group C by fire acupuncture combined with 5-aminolevulinic acid photodynamic therapy.The scores of skin lesions,clinical effective rate and recurrence rate of the three groups were compared.Results Before treatment,the scores of skin lesions were 6.25±2.06 in group A,6.21±2.13 in group B and 6.23±2.09 in group C.After treatment,the scores of skin lesions were 3.17±0.93 in group A,3.10±1.07 in group B and 1.92±0.81 in group C.In the three groups,there was significant difference between the scores of skin lesions before and after treatment(P<0.05).To be compared with group A and group B,the scores of skin lesions of group C were significantly reduced after treatment(P<0.05);the total effective rate was 76.7%in group A,73.3%in group B and 90.0%in group C.The total effective rate of group C was significantly higher than that of group A and group B(P<0.05).One year follow-up showed that the recurrence rate was 30.4%in group A,31.8%in group B and 11.1%in group C.The recurrence rate of group C was significantly lower than that of group A and group B(P<0.05).Conclusion Fire-needle combined with 5-aminolevulinic acid photodynamic therapy is safe and effective in the treatment of facial refractory flat warts.

关 键 词：扁平疣 火针 5-氨基酮戊酸 光动力疗法 

分 类 号：R759.13[医药卫生—皮肤病学与性病学]