Interspecies transmission and evolution of the emerging coronaviruses: perspectives from bat physiology and protein spatial structure  

作　　者：Baicheng HUANG Kegong TIAN 

机构地区：[1]National Research Center for Veterinary Medicine,Luoyang 471003,China [2]College of Animal Science and Veterinary Medicine,Henan Agricultural University,Zhengzhou 450046,China

出　　处：《Frontiers of Agricultural Science and Engineering》2020年第2期218-226,共9页农业科学与工程前沿（英文版）

基　　金：funded by Luoyang Heluo Talent Plan。

摘　　要：Emergent coronaviruses(CoVs)such as SARS-CoV and MERS-CoV have posed great threats to public health worldwide over the past two decades.Currently,the emergence of SARS-CoV-2 as a pandemic causes greater public health concern.CoV diversity is due to the large size and replication mechanisms of the genomes together with having bats as their optimum natural hosts.The ecological behavior and unique immune characteristics of bats are optimal for the homologous recombination of CoVs.The relationship of spatial structural characteristics of the spike protein,a protein that is critical for recognition by host receptors,in different CoVs may provide evidence in explaining the coevolution of CoVs and their hosts.This information may help to enhance our understanding of CoV evolution and thus provide part of the basis of preparations for any future outbreaks.

关 键 词：BAT CORONAVIRUS EVOLUTION host receptor spike protein transmission 

分 类 号：S852.65[农业科学—基础兽医学]