5-氨基酮戊酸光动力疗法治疗宫颈高危型HPV感染疗效的Meta分析  

Efficacy of 5-aminolevulinic acid photodynamic therapy for high-risk HPV infection: a Meta-analysis

作　　者：岳阿兰 韩霞[1] YUE A-lan;HAN Xia(Department of Gynecology,Shenzhen Hospital of Guangzhou University of Chinese Medicine,Shenzhen 518000,China)

机构地区：[1]广州中医药大学深圳医院妇科 [2]广州中医药大学第六临床医学院

出　　处：《临床皮肤科杂志》2020年第7期403-408,共6页Journal of Clinical Dermatology

基　　金：深圳市福田区科技局基金项目(FTWS2017034);深圳市福田区卫生公益性科研项目(FTW2019030)。

摘　　要：目的:系统评价5-氨基酮戊酸光动力疗法(ALA-PDT)对宫颈高危型人乳头瘤病毒(HR-HPV)感染治疗的疗效和安全性。方法:计算机检索PubMed、Web of Science、Embase、Ovid MEDLINE、EBM Reviews—Cochrane Central Register of Con trolled Trials、中国知网(CNKI)、中文科技期刊数据库(VIP)和万方数据库(wanfang database)中的随机对照试验。依照事先制定的纳入标准和排除标准对文献进行筛选、数据提取和质量评价,应用Revman 5.3进行统计分析。结果:共纳入11篇文献,Meta分析结果显示,ALA-PDT治疗后3、6、9及12个月的HPV转阴率分别是对照组的3.5、4.12、2.28及2.4倍。结论:ALA-PDT治疗宫颈HR-HPV感染不仅疗效明显,且治疗结果较稳定,值得临床推广与应用。Objective: To assess the efficacy and safety of 5-aminolevulinic acid photodynamic therapy(ALA-PDT) in treating high-risk HPV cervical infection. Methods: Randomized controlled trials(RCTs) were searched in PubMed, Web of Science, Embase, Ovid MEDLINE, EBM Reviews-Cochrane Central Register of Controlled Trials, CNKI, VIP and Wanfang databases.Literature screening, data extraction and quality evaluation were conducted according to the pre-established inclusion and exclusion criteria. Statistical analysis was performed using Revman 5.3. Results: A total of eleven articles were included. Metaanalysis showed that the HPV negative conversion rate at 3, 6, 9 and 12 months after ALA-PDT treatment was 3.5, 4.12,2.28 and 2.4 times of the control group, respectively. Conclusion: ALA-PDT is not only significantly effective, but also stable in treating HR-HPV cervical infection. Therefore, it is worthy of promotion in clinical practice.

关 键 词：高危型HPV感染 光动力疗法 HPV转阴率 

分 类 号：R711.74[医药卫生—妇产科学]