SARS-CoV-2 infection in infants under 1 year of age in Wuhan City, China  

作　　者：Dan Sun Xue Chen Hui Li Xiao-Xia Lu Han Xiao Fu-Rong Zhang Zhi-Sheng Liu 

机构地区：[1]Department of Neurology,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China [2]Department of Hematology,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei,China [3]Department of Respiratory Diseases,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China [4]Institute of Maternal and Child Health,Wuhan Children's Hospital,Tongji Medical College,Huazhong University and Technology,Wuhan,China [5]Department of Intensive Care Unit,Wuhan Children's Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,China

出　　处：《World Journal of Pediatrics》2020年第3期260-266,共7页世界儿科杂志（英文版）

基　　金：We would like to thank the parents and children for participating in the study.We thank the doctors and nursing stafF of Wuhan Children's Hospital for their detailed assessments and dedicated care of these infant patients.

摘　　要：Background The clinical characteristics and outcome of COVID-19 in children are different from those in adults.We aimed to describe the characteristics of infants under 1 year of age (excluding newborns) with COVID-19.Methods We retrospectively retrieved data of 36 infants with SARS-CoV-2 infection in Wuhan Children's Hospital from January 26 to March 22,2020.Clinical features,chest imaging findings,laboratory tests results,treatments and clinical outcomes were analyzed.Results The mean age of the infected infants was 6.43 months,with a range of 2-12 months.61.11% of the patients were males and 38.89% females.86.11% of the infants were infected due to family clustering.Cough (77.78%) and fever (47.22%) were the most common clinical manifestations.Chest CT scan revealed 61.11% bilateral pneumonia and 36.11% unilateral pneumonia.47.22% of the infants developed complications.Increased leucocytes,neutrophils,lymphocytes,and thrombocytes were observed in 11.11,8.33,36.11 and 44.44% of infants,respectively.Decreased leucocytes,neutrophils,thrombocyte and hemoglobin were observed in 8.33,19.44,2.78 and 36.11% of infants,respectively.Increased C-reactive protein,procalcitonin,lactate dehydrogenase,alanine aminotransferase,creatine kinase and D-dimer were observed in 19.44,67.74,47.22,19.44,22.22 and 20.69% of infants,respectively.Only one infant had a high level of creatinine.Co-infections with other respiratory pathogens were observed in 62.86% of infants.CD3 (20.69%),CD4 (68.97%),CD19 (31.03%) and Th/Ts (44.83%) were elevated;CD8 (6.9%) and CD16+CD56 (48.28%) was reduced.IL-4 (7.69%),IL-6 (19.23%),IL-10 (50%),TNF-α (11.54%) and IFN-γ (19.23%) were elevated.Up to March 22,97.22% of infants recovered,while a critical ill infant died.When the infant's condition deteriorates rapidly,lymphocytopenia was discovered.Meanwhile,C-reactive protein,D-dimer,alanine aminotransferase,creatine kinase,creatinine,IL-6 and IL-10 increased significantly.Conclusions In the cohort,we discovered that lymphocytosis,elevated CD4 and IL-10,a

关 键 词：COVID-19 Coronavirus infant infection SARS-CoV-2 

分 类 号：R725.6[医药卫生—儿科]