血液透析、灌流对糖尿病肾病患者血清TNF-α、CRP、IL-6水平的影响  

Effect of Hemodialysis and Perfusion on the Serum TNF-α, CRP and IL-6 Levels in the Patients with Diabetic Nephropathy

作　　者：孙燕[1] 曹丽 董倩兰[1] 王琼[1] 高瑞瑞 SUN Yan;CAO Li;DONG Qian-lan;WANG Qiong;GAO Rui-rui(Nephrological Hemodialysis Center,Shaanxi Provincial People's Hospital,Xi'an,Shaanxi,710068,China;Department of Nephrology,Yulin NO.2 Hospital,Yulin,Shaanxi,719000,China)

机构地区：[1]陕西省人民医院肾病血透中心,陕西西安710068 [2]榆林市第二医院肾病内科,陕西榆林719000

出　　处：《现代生物医学进展》2020年第12期2325-2328,共4页Progress in Modern Biomedicine

基　　金：陕西省重点研发项目:一般项目-社会发展领域(2018SF-168)。

摘　　要：目的:探讨血液透析辅助血液灌流对终末期糖尿病肾病血清C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子(tumor necrosis factor,TNF-α)及白细胞介素(Interleukin,IL)-6水平的影响。方法:选取近3年收治的79例糖尿病肾病患者,将其随机分为研究组(n=40)和对照组(n=39),对照组患者接受血液透析治疗,研究组患者接受血液透析辅助血液灌流治疗,对比两组患者治疗前后血清TNF-α、CRP、IL-6水平的变化情况。结果:治疗后,研究组患者的治疗总有效率、血红蛋白(haemoglobin,Hb)、转铁蛋白水平(transferring,TRF)、白蛋白(albumin,Alb)及营养不良-炎症评分(malnutrition inflammation score,MIS)均明显高于对照组(P<0.05),而MIS评分明显低于对照组(P<0.05);两组患者治疗后血清CRP、TNF-α、IL-6水平均明显低于治疗前(P<0.05),且研究组患者以上指标明显低于对照组(P<0.05)。结论:血液透析辅助血液灌流治疗糖尿病肾病可显著改善患者的临床症状和营养状态,降低TNF-α、CRP、IL-6水平,减轻炎症反应。Objective: To investigate the effect of hemodialysis assisted hemoperfusion on serum TNF-α, CRP, IL-6 levels in end-stage diabetic nephropathy. Methods: 79 patients with diabetic nephropathy admitted in the past 3 years were randomly divided into the study group(n=40) and the control group(n=39). The control group received hemodialysis treatment. The study group received hemodialysis assistance blood perfusion. Treatment, comparing the changes of serum TNF-α, CRP and IL-6 levels before and after treatment in the two groups. Results: After treatment, the total effective rate of treatment, hemoglobin(Hb), transferrin(TRF), albumin(Alb), and malnutrition inflammation score(MIS) were all in the study group. The MIS score was significantly lower than that of the control group(P<0.05). The levels of serum CRP, TNF-α and IL-6 in the two groups were significantly lower than those before treatment(P<0.05), and the above indicators of the study group were significantly lower than the control group(P<0.05). Conclusion:Hemodialysis-assisted blood perfusion for the treatment of diabetic nephropathy can significantly improve the clinical symptoms and nutritional status of patients, reduce TNF-α, CRP, IL-6 levels, reduce inflammation.

关 键 词：血液透析 血液灌流 糖尿病肾病 TNF-α CRP IL-6 

分 类 号：R587.2[医药卫生—内分泌]