Approaches to promoting bone marrow mesenchymal stem cell osteogenesis on orthopedic implant surface  

作　　者：Shi-Cheng Huo Bing Yue 

机构地区：[1]Department of Bone and Joint Surgery,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200011,China

出　　处：《World Journal of Stem Cells》2020年第7期545-561,共17页世界干细胞杂志（英文版）（电子版）

基　　金：Supported by Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support,No.20161423.

摘　　要：Bone marrow-derived mesenchymal stem cells(BMSCs)play a critical role in the osseointegration of bone and orthopedic implant.However,osseointegration between the Ti-based implants and the surrounding bone tissue must be improved due to titanium’s inherent defects.Surface modification stands out as a versatile technique to create instructive biomaterials that can actively direct stem cell fate.Here,we summarize the current approaches to promoting BMSC osteogenesis on the surface of titanium and its alloys.We will highlight the utilization of the unique properties of titanium and its alloys in promoting tissue regeneration,and discuss recent advances in understanding their role in regenerative medicine.We aim to provide a systematic and comprehensive review of approaches to promoting BMSC osteogenesis on the orthopedic implant surface.

关 键 词：Bone marrow mesenchymal stem cells OSSEOINTEGRATION Orthopedic implant BIOFUNCTIONALIZATION 

分 类 号：R318.08[医药卫生—生物医学工程]