Decellularized adipose matrix provides an inductive microenvironment for stem cells in tissue regeneration  

作　　者：Ji-Zhong Yang Li-Hong Qiu Shao-Heng Xiong Juan-Li Dang Xiang-Ke Rong Meng-Meng Hou Kai Wang Zhou Yu Cheng-Gang Yi 

机构地区：[1]Department of Plastic Surgery,Xijing Hospital,Fourth Military Medical University,Xi'an 710032,Shaanxi Province,China

出　　处：《World Journal of Stem Cells》2020年第7期585-603,共19页世界干细胞杂志（英文版）（电子版）

摘　　要：Stem cells play a key role in tissue regeneration due to their self-renewal and multidirectional differentiation,which are continuously regulated by signals from the extracellular matrix(ECM)microenvironment.Therefore,the unique biological and physical characteristics of the ECM are important determinants of stem cell behavior.Although the acellular ECM of specific tissues and organs(such as the skin,heart,cartilage,and lung)can mimic the natural microenvironment required for stem cell differentiation,the lack of donor sources restricts their development.With the rapid development of adipose tissue engineering,decellularized adipose matrix(DAM)has attracted much attention due to its wide range of sources and good regeneration capacity.Protocols for DAM preparation involve various physical,chemical,and biological methods.Different combinations of these methods may have different impacts on the structure and composition of DAM,which in turn interfere with the growth and differentiation of stem cells.This is a narrative review about DAM.We summarize the methods for decellularizing and sterilizing adipose tissue,and the impact of these methods on the biological and physical properties of DAM.In addition,we also analyze the application of different forms of DAM with or without stem cells in tissue regeneration(such as adipose tissue),repair(such as wounds,cartilage,bone,and nerves),in vitro bionic systems,clinical trials,and other disease research.

关 键 词：Extracellular matrix Decellularized adipose matrix Decellularized adipose tissue Adipose-derived extracellular matrix Adipose tissue extracellular matrix Adipose matrix Stem cells Soft tissue regeneration Decellularization methods 

分 类 号：R318[医药卫生—生物医学工程]