脊髓星形胶质细胞在慢性周围神经病理性疼痛中的作用及中医药干预研究进展  

The role of spinal astrocytes in chronic peripheral neuropathic pain and the research progress of traditional Chinese medicine intervention

作　　者：金桑懿 姚政[1] JIN Shen-yi;YAO Zheng(Department of Endocrinology.Shuguang Hospital Affliated to Shanghai University of Traditional Chinese Medicine,Shanghai201203,China)

机构地区：[1]上海中医药大学附属曙光医院内分泌科,上海201203

出　　处：《世界临床药物》2020年第6期410-415,共6页World Clinical Drug

基　　金：国家自然科学基金(81503552,81874434);上海市科委科研计划项目(17401970100,17401970600);中医糖尿病专科联盟建设[ZY(2018-2020)-FWTX-4011];上海市中医临床重点实验室(14DZ2273200);上海市临床重点专科(shslczdzk05401)。

摘　　要：慢性周围神经病理性疼痛是临床上常见难题,严重影响患者的生活质量。近年来多项研究显示,脊髓星形胶质细胞活化后可通过调节脊髓伤害性突触传递参与疼痛信号传导,提示靶向脊髓星形胶质细胞活化的特定途径可能是中医药治疗慢性周围神经病理性疼痛的新策略。本文对脊髓星形胶质细胞在慢性周围神经病理性疼痛中的作用及中医药干预研究进展作一综述。Chronic peripheral neuropathic pain is a common clinical problem that seriously affects the quality of life of patients.In recent years,it has been discovered that activated spinal astrocytes can participate in pain signal conduction by regulating spinal nociceptive synaptic transmission.It shows that the specific pathway targeting the activation of spinal astrocytes may be a new strategy of the treatment of chronic peripheral neuropathic pain in traditional Chinese medicine.This paper reviewed the role of spinal astrocytes in chronic peripheral neuropathic pain and the progress of intervention research with traditional Chinese medicine.

关 键 词：脊髓星形胶质细胞 慢性周围神经病理性疼痛 中医药 

分 类 号：R587.1[医药卫生—内分泌] R651.3[医药卫生—内科学]