Comparative efficacy of honey 12.5% and chlorhexidine 0.2% mouthwashes on the oropharyngeal bacterial colonization in mechanically-ventilated patients: a randomized controlled trial  

作　　者：Halimeh Amiri Farhad Ramezani-Badr Naseh Sigari Karim Nasseri 

机构地区：[1]Department of Critical Care Nursing,School of Nursing and Midwifery,Zanjan University of Medical Sciences,Zanjan 4515613191,Iran [2]Department of Intrenal Medicine,Kurdistan University of Medical Sciences,Sanandaj 66614713446,Iran [3]Department of Anesthesiology,Faculty of Medicine,Kurdistan University of Medical Sciences,Sanandaj 66614713446,Iran

出　　处：《Journal of Traditional Chinese Medicine》2020年第3期440-446,共7页中医杂志（英文版）

基　　金：Supported by a grant from the Zanjan University of Medical Sciences Vice chancellor for research(No.ZUMS.REC.1392.40)。

摘　　要：OBJECTIVE: To compare the efficacy of honey mouthwash 12.5% and chlorhexidine solution 0.2%to reduce the rate of oropharyngeal bacterial colonization in mechanically-ventilated patients.METHODS: This study was a randomized, single blind, phase Ⅲ controlled clinical trial. Sixty patients newly admitted to internal and trauma Intensive Care Units of the two educational hospitals of Sanandaj city affiliated with Kurdistan University of Medical Sciences were selected by convenience sampling and allocated to two groups of 30 patients using random blocks design. In each group,the mouthwash was applied twice a day for four consecutive days. Swab samples were taken from the mouth and throat of all patients three times a day(pre-intervention, two days, and four days after the intervention) and then the samples were transferred onto the blood agar and eosin methylene blue(EMB) culture plates and investigated for bacterial growth and colonization after 24-48 h.RESULTS: The findings showed that oropharyngeal colonization was not significantly different between the two groups, pre-intervention, two days,and four days after the intervention(P > 0.05). Rinsing with honey mouthwash 12.5% led to the inhibition of Staphylococcus aureus and Pseudomonas aeruginosa on the fourth day of the intervention in all samples.CONCLUSION: None of the studied solutions contributed to the reduction of oropharyngeal bacterial colonization. It seems that the growth inhibition of Staphylococcus aureus and Pseudomonas aeruginosa by the honey 12.5% mouthwash in mechanically-ventilated patients need further investigation.

关 键 词：Mouthwashes HONEY CHLORHEXIDINE VENTILATORS MECHANICAL Oropharyngeal colonization Intensive Care Unit Randomized controlled trial 

分 类 号：R248[医药卫生—中医临床基础]