Effect of Huatan Jieyu granules in treatment of Parkinson’s disease patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind  

作　　者：Liu Meijun Hu Chongshan Zhang Yaodan Li Qizheng Zhang Qi Fang Yu Sun Honghui Hou Xiaolin Jin Shuoguo Tao Liangjing Yang Dongdong 

机构地区：[1]Medical Department of Neurology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China [2]School of Clinical Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China [3]Surgical Department of Neurosurgery,Hospital of Chengdu University of Traditional Chinese Medicine,Sichuan Province,Chengdu 610072,China

出　　处：《Journal of Traditional Chinese Medicine》2020年第3期461-466,共6页中医杂志（英文版）

基　　金：Supported by Clinical Study on Treatment of Parkinson’s Disease with Sleep Disorder in Symptom Pattern of Phlegma-heat-stirring Wind Due to by Huatan Jieyu granules (No.2017-D-YY-70)。

摘　　要：OBJECTIVE: To investigate the safety and efficacy of Huatan Jieyu granules in treatment of Parkinson’s disease(PD) patients with sleep disorder identified as symptom pattern of phlegma-heat-stirring wind in terms of the theory of Traditional Chinese Medicine.METHODS: In total, 107 Parkinson’s disease patients with sleep disorders identified as symptom pattern of phlegma-heat-stirring wind were selected and randomly divided into the experimental group(55 cases) and the control group(52 cases).Both groups were given basic treatment with prednisone. The experimental group of patients was treated with Huatan Jieyu granules and the control group of patents was treated with only the basic treatment. Treatment lasted for 4 weeks. Sleep polygraph were recorded before the study as well as 3 months and 6 months after treatment.RESULTS: After treated with Huatan Jieyu granules,the total sleep time, and the percentage of non rapid eye movement 2(NREM 2), non rapid eye movement 3(NREM 3) and rapid eye movement(REM)sleep period increased significantly, while the percentage of NREM1 sleep period decreased significantly compared with before treatment(P < 0.05).CONCLUSION: The treatment of PD patients with sleep disorder by Huatan Jieyu granules can improve their sleep structure and their sleep quality.

关 键 词：Parkinson disease Sleep disorder Phlegma-heat-stirring wind Sleep polygraph Huatan Jieyu granules 

分 类 号：R277.7[医药卫生—中医学]