血清NT-proBNP、Copeptin、MMP-9及HMGB1表达水平在重症肺炎患者中的意义  

Significance of the expression levels of serum NT-proBNP,copeptin,MMP9 and HMGB1 in patients with severe pneumonia

作　　者：段志辉[1] 程晓伟[1] 曹友林 马玥[1] DUAN Zhi-hui;CHENG Xiao-wei;CAO You-lin;MA Yue(Panzhihua Central Hospital,Sichuan Province,Panzhihua,Sichuan 617067,China)

机构地区：[1]四川省攀枝花市中心医院,四川攀枝花617067

出　　处：《热带医学杂志》2020年第6期787-790,共4页Journal of Tropical Medicine

基　　金：四川省卫生厅科研基金(140041)。

摘　　要：目的探讨血清N末端-脑钠肽前体(NT-proBNP)、和肽素(Copeptin)、基质金属蛋白酶9(MMP-9)、高迁移率族蛋白1(HMGB1)表达与重症肺炎患者病情及预后的关系。方法选取2016年1月-2018年1月攀枝花市中心医院重症医学科确诊的90例重症肺炎患者(重症组)、呼吸内科收集的90例普通肺炎患者(对照组),检测两组的血清NT-proBNP、Copeptin、MMP9及HMGB1水平,并探讨重症肺炎患者血清NT-proBNP、Copeptin、MMP-9及HMGB1水平与患者预后、急性生理功能与慢性健康(APACHEⅡ)评分、临床肺部感染评分(CPIS)的关系。结果重症组患者体温、心率(RR)、收缩压(SBP)、呼吸频率(HR)、白细胞(WBC)、APACHEⅡ评分、CPIS评分均显著高于对照组(P<0.05);重症组患者的血清NT-proBNP、Copeptin、MMP-9及HMGB1水平均显著高于对照组(P<0.05);死亡组重症肺炎患者的血清NT-proBNP、Copeptin、MMP-9及HMGB1水平均显著高于存活组(P<0.05);重症肺炎患者的血清NT-proBNP、Copeptin、MMP-9及HMGB1水平与APACHEⅡ评分、CPIS评分均呈显著的正相关关系(P<0.05)。结论重症肺炎患者的血清NT-proBNP、Copeptin、MMP-9及HMGB1水平较普通肺炎患者显著升高,并且与患者感染病情及预后不良有密切关系。Objective To investigate the serum N-terminal pro-brain natriuretic peptide(NT-proBNP),and copeptin(Copeptin),matrix metalloproteinase 9(MMP-9),high mobility group protein 1(HMGB1) and the severity and prognosis of patients with severe pneumonia relationships.Methods Ninety patients with severe pneumonia(severe group) and 90 patients with common pneumonia(control group) collected from the Department of Critical Care Medicine in our hospital from January 2016 to January 2018 were enrolled.Serum NT-proBNP was measured in both groups.The relationships between serum NT-proBNP,Copeptin,MMP-9 and HMGB1 levels in patients with severe pneumonia and their prognosis,acute physiological function and chronic health(APACHE Ⅱ) score,clinical pulmonary infection score(CPIS) were analyzed.Results The body temperature,RR,SBP,HR,WBC,APACHE Ⅱ score,and CPIS scores of the severe group were significantly higher than those of the control group(P<0.05).The DBP difference between the severe group and the control group was not statistically significant(P>0.05).Serum NT-proBNP,Copeptin,MMP-9 and HMGB1 levels were significantly higher in the severe group than those in the control group(P<0.05);serum NT-proBNP,Copeptin,MMP9 and HMGB1 were significantly higher in the severe group of patients with severe pneumonia.The levels of serum NT-proBNP,Copeptin,MMP-9 and HMGB1 in patients with severe pneumonia were positively correlated with APACHE Ⅱ score and CPIS score(P<0.05).Conclusion The levels of serum NT-proBNP,Copeptin,MMP-9 and HMGB1 in patients with severe pneumonia were significantly higher than those in patients with common pneumonia,and were closely related to the patient’s infection and poor prognosis.

关 键 词：N末端-脑钠肽前体 和肽素 基质金属蛋白酶9 高迁移率族蛋白1 重症肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]