急性缺血性脑卒中患者血清TIGAR mRNA水平及其与预后的关系  

Serum TIGAR mRNA level in patients with acute ischemic stroke and its relationship with prognosis

作　　者：喻长莉 李建军 YU Changli;LI Jianjun(The Traditional Chinese Medicine Hospital of Jiangxia District,Wuhan,Hubei 430200,China)

机构地区：[1]武汉市江夏区中医医院,湖北省武汉市430200

出　　处：《中国动脉硬化杂志》2020年第7期589-593,共5页Chinese Journal of Arteriosclerosis

基　　金：湖北省自然科学基金项目(2012FFB04416)。

摘　　要：目的探讨急性缺血性脑卒中患者血清tp53诱导的糖酵解和凋亡调节因子(TIGAR)mRNA水平及其与预后的关系。方法选取247例急性缺血性脑卒中患者为研究对象。收集患者年龄、性别、体质指数、高血压、高脂血症、糖尿病、冠心病、吸烟、脑卒中分布、脑卒中发病时间、TOAST病因学分型、严重程度、脑卒中病灶数、出血转化、同型半胱氨酸(Hcy)、C反应蛋白(CRP)、D二聚体(D-D)、糖化血红蛋白A1c(HbA1c)、血管生成素1(Ang-1)等资料。采用实时荧光定量PCR法(qRT-PCR)检测血清TIGAR mRNA相对表达量,并分析其与预后的关系。结果247例急性缺血性脑卒中患者90天内预后不良发生率为47.77%。预后良好组TIGAR mRNA相对表达量明显高于预后不良组(P<0.05)。TIGAR mRNA评估急性缺血性脑卒中患者预后的曲线下面积AUC、敏感度、特异度分别为0.886、88.14%、80.62%。Logistic多因素回归分析显示脑卒中发病时间、TOAST病因学分型、严重程度、出血转化及TIGAR mRNA与急性缺血性脑卒中患者预后关系密切。结论血清TIGAR mRNA相对表达量越高,急性缺血性脑卒中患者预后越好,检测TIGAR mRNA相对表达量有助于评估患者预后情况。Aim To investigate the level of serum tp53-induced glycolysis and apoptotic and regulator(TIGAR)mR NA in patients with acute ischemic stroke and its relationship with prognosis.Methods 247 patients with acute ischemic stroke were selected as the study object.The age,sex,body mass index,hypertension,hyperlipidemia,diabetes,coronary heart disease,smoking,stroke distribution,stroke onset time,toast etiology,severity,stroke focus number,hemorrhage transformation,homocysteine(Hcy),C-reactive protein(CRP),D-Dimer(D-D),hemoglobin A1 c(HbA 1 c),angiopoietin-1(Ang-1)of patients were collected.Real-time fluorescence quantitative PCR(qR T-PCR)was used to detect the relative expression of serum TIGAR mR NA,and its relationship with prognosis was analyzed.Results The incidence of poor prognosis in 247 patients with acute ischemic stroke was 47.77%within 90 days.The relative expression of TIGAR mR NA in the prognosis group was significantly higher than that in the poor prognosis group,and the difference was statistically significant(P<0.05).The area under the curve AUC,sensitivity and specificity of TIGAR mR NA in evaluating the prognosis of patients with acute ischemic stroke were 0.886,88.14%and 80.62%,respectively.Logistic multivariate regression analysis showed that the onset time of stroke,TOAST etiology classification,severity,hemorrhagic transformation and TIGAR mR NA were closely related to the prognosis of patients with acute ischemic stroke.Conclusion The higher the relative expression of TIGAR mR NA in serum,the better the prognosis of patients with acute ischemic stroke.Detection of relative expression of TIGAR mR NA is helpful to assess the prognosis of patients.

关 键 词：急性缺血性脑卒中 tp53诱导的糖酵解和凋亡调节因子 预后 

分 类 号：R543[医药卫生—心血管疾病]