赤芍中的1个新木脂素苷类化合物  

A new lignan glucoside from root of Paeonia lactiflora

作　　者：钟万超 李瑞 夏欢 夏桂阳 张景芳 田贵华[2] 林生 ZHONG Wan-chao;LI Rui;XIA Huan;XIA Gui-yang;ZHANG Jing-fang;TIAN Gui-hua;LIN Sheng(State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China;Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospitals,Beijing University of Chinese Medicine,Beijing 100700,China)

机构地区：[1]中国医学科学院北京协和医学院药物研究所天然药物活性物质与功能国家重点实验室,北京100050 [2]北京中医药大学东直门医院中医内科学教育部/北京重点实验室,北京100700

出　　处：《中国中药杂志》2020年第12期2903-2906,共4页China Journal of Chinese Materia Medica

基　　金：国家自然科学基金项目(81773589,81522050);中国医学科学院医学与健康科技创新工程项目(2017-IZM-3-010);国家“重大新药创制”科技重大专项(2018ZX09711001-001)。

摘　　要：通过正相硅胶、凝胶、大孔吸附树脂和反相HPLC多种色谱技术,从赤芍水提取物中分离得到1个新木脂素苷(1),经UV,IR,HRESI-MS,CD,1D和2D NMR波谱学方法以及化学方法鉴定其结构为(+)-肉豆蔻素A2-4-O-β-D-吡喃葡萄糖苷。化合物1对LPS诱导的RAW264.7细胞NO的释放具有较强的抑制活性,IC50为21.3μmol·L^-1。A new lignan glucoside,(+)-fragransin A2-4-O-β-D-glucopyranoside(1),has been isolated from the dry root of Paeonia lactiflora by column chromatography on silica gel,Sephadex LH-20,and MCI-gel resin,as well as preparative RP-HPLC.The structure of the new compound was elucidated by spectroscopic data analysis(MS,UV,IR,CD,1 D and 2 D NMR)and chemical method.Compound 1 showed moderate inhibition against lipopolysaccharide induced nitric oxide production in RAW264.7 macrophages,with an IC50 value of 21.3μmol·L^-1.

关 键 词：赤芍 化学成分 木脂素苷 NO抑制活性 

分 类 号：R284[医药卫生—中药学]