Improved diagnostic yield of endoscopic ultrasound-fine needle biopsy with histology specimen processing  

作　　者：Lawrence Ku Mohammad A Shahshahan Linda A Hou Viktor E Eysselein Sofiya Reicher 

机构地区：[1]Department of Medicine,Division of Gastroenterology and Hepatology,Harbor-UCLA Medical Center,Torrance,CA 90509,United States

出　　处：《World Journal of Gastrointestinal Endoscopy》2020年第8期212-219,共8页世界胃肠内镜杂志（英文版）（电子版）

基　　金：Supported by the National Center for Advancing Translational Sciences through University of California,Los Angeles Clinical and Translational Science Institute Grant,No.UL1TR001881-01.

摘　　要：BACKGROUND Endoscopic ultrasound-guided fine needle biopsy(EUS-FNB)has emerged as a safe,efficacious alternative to fine needle aspiration(FNA)for tissue acquisition.EUS-FNB is reported to have higher diagnostic yield while preserving specimen tissue architecture.However,data on the optimal method of EUS-FNB specimen processing is limited.AIM To evaluate EUS-FNB with specimen processing as histology vs EUS-FNA cytology with regards to diagnostic yield and specimen adequacy.METHODS All EUS-FNA and EUS-FNB performed at our institution from July 1,2016,to January 31,2018,were retrospectively analyzed.We collected data on demographics,EUS findings,pathology,clinical outcomes,and procedural complications in two periods,July 2016 through March 2017,and April 2017 through January 2018,with predominant use of FNB in the second data collection time period.FNA specimens were processed as cytology with cell block technique and reviewed by a cytopathologist;FNB specimens were fixed in formalin,processed for histopathologic analysis and immunohistochemical staining,and reviewed by an anatomic pathologist.Final diagnosis was based on surgical pathology when available,repeat biopsy or imaging,and length of clinical follow up.RESULTS One hundred six EUS-FNA and EUS-FNB procedures were performed.FNA alone was performed in 17 patients;in 56 patients,FNB alone was done;and in 33 patients,both FNA and FNB were performed.For all indications,diagnostic yield was 47.1%(8/17)in FNA alone cases,85.7%(48/56)in FNB alone cases,and 84.8%(28/33)in cases where both FNA and FNB were performed(P=0.0039).Specimens were adequate for pathologic evaluation in 52.9%(9/17)of FNA alone cases,in 89.3%(50/56)of FNB alone cases,and 84.8%(28/33)in cases where FNA with FNB were performed(P=0.0049).Tissue could not be aspirated for cytology in 10.0%(5/50)of cases where FNA was done,while in 3.4%(3/89)of FNB cases,tissue could not be obtained for histology.In patients who underwent FNA with FNB,there was a statistically significant difference in both specime

关 键 词：Fine needle biopsy Endoscopic ultrasound Fine needle aspiration Pancreatic cancer HISTOLOGY CYTOPATHOLOGY 

分 类 号：R446.8[医药卫生—诊断学]