北京市161名新生儿脐带血中邻苯二甲酸酯代谢物含量与出生指标的关联分析  

A study on the correlation of phthalate metabolites in umbilical cord blood of 161 newborns with birth indicators in Beijing

作　　者：苗宏健 张磊 赖建强 孙亮 赵云峰 李敬光 Miao Hongjian;Zhang Lei;Lai Jianqiang;Sun Liang;Zhao Yunfeng;Li Jingguang(Chemistry Laboratory,China National Center for Food Safety and Risk Assessment/NHC Key Laboratory of Food Safety Risk Assessment,Beijing 100021,China;National Insititute for Nutrition and Health,Chinese Center for Disease Control and Prevention,Beijing 100050,China;Technical Service Department,Shimadzu Scientific Instrument Company,Beijing 100020,China)

机构地区：[1]国家食品安全风险评估中心化学实验室国家卫生健康委食品安全风险评估重点实验室,北京100021 [2]中国疾病预防控制中心营养与健康所,北京100050 [3]岛津企业管理(中国)有限公司技术服务部,北京100020

出　　处：《中华预防医学杂志》2020年第7期768-773,共6页Chinese Journal of Preventive Medicine

基　　金：国家重点研发计划(2017YFC1600500)。

摘　　要：目的分析北京市新生儿脐带血中邻苯二甲酸酯代谢物含量与新生儿出生指标的关联。方法于2015年2—7月,在北京市海淀区妇幼保健医院招募符合标准的待产孕妇及其新生儿为研究对象,共纳入161对孕妇及新生儿。问卷调查孕妇年龄、吸烟、饮酒等人口学信息,并在分娩后采集脐带血。采用超高效液相色谱‐三重四极杆质谱仪测定脐带血邻苯二甲酸酯代谢物含量,并采用多元线性回归模型分析其与新生儿体重、身长和出生体重指数的关联。结果161名孕妇年龄为(30.3±3.0)岁;161名婴儿体重为(3447.2±413.0)kg,身长为(50.2±1.1)cm,出生体重指数为(26.7±2.2)kg/m3,男婴占51.6%(83名)。脐带血中检出的7种邻苯二甲酸酯代谢物:邻苯二甲酸甲酯、邻苯二甲酸异丁酯、邻苯二甲酸丁酯、邻苯二甲酸单‐2‐乙基己酯、邻苯二甲酸单(2‐乙基‐5‐氧己基)酯、邻苯二甲酸单(2‐乙基‐5‐羧基戊基)酯和邻苯二甲酸乙酯含量分别为(3.50±0.28)、(2.65±0.47)、(4.31±0.55)、(6.26±0.57)、(1.71±0.13)、(1.10±0.09)、(0.47±0.06)ng/ml。多元线性回归模型分析结果显示,7种邻苯二甲酸酯代谢物含量与新生儿体重、身长和出生体重指数均无关联(P值均>0.05)。结论北京市新生儿脐带血中邻苯二甲酸酯代谢物的含量较低,与新生儿体重、身长和出生体重指数无关联。Objective To analyze the correlation of phthalate metabolites in neonatal umbilical cord blood with birth indicators in Beijing,2015.Method From February to July in 2015,161 pregnant women and their newborns who met the criteria were recruited from the Maternal and Child Health Hospital in Haidian District,Beijing.Questionnaires were used to collect the demographic information of pregnant women such as age,smoking,drinking,and cord blood after delivery.An ultra‑high performance liquid chromatography‑tandem mass spectrometry was used to determine the concentration of phthalate metabolites in umbilical cord blood.The multiple linear regression model was used to analyze the correlation of phthalate metabolites in umbilical cord blood with the neonatal weight,length,and ponderal index.Result The age of 161 pregnant women was(30.3±3.0)years.The weight,length and ponderal index of 161 newborns were(3447.2±413.0)kg,(50.2±1.1)cm,and(26.7±2.2)kg/m3;51.6%of newborns(83 cases)were boys.The concentrations of seven phthalate metabolites detected in umbilical cord blood,i.e.,mono‑methyl phthalate(MMP),mono‑ethyl phthalate(MEP),mono‑(2‑isobutyl)phthalate(MiBP),mono‑n‑butyl phthalate(MBP),mono‑ethylhexyl phthalate(MEHP),mono‑(2‑ethyl‑5‑oxohexyl)phthalate(MEOHP),and mono‑(2‑ethyl‑5‑carboxypentyl)phthalate(MECPP),was(3.50±0.28),(2.65±0.47),(4.31±0.55),(6.26±0.57),(1.71±0.13),(1.10±0.09)and(0.47±0.06)ng/ml,respectively.The result of multiple linear regression model analysis showed that the concentrations of seven phthalate metabolites were not related to the neonatal weight,length,and ponderal index(all P values>0.05).Conclusion The concentrations of phthalate metabolites in neonatal umbilical cord blood are low,and they are not related to the neonatal weight,length,and ponderal index.

关 键 词：胎血 横断面研究 邻苯二甲酸酯代谢物 

分 类 号：R722.1[医药卫生—儿科]