"H型"高血压患者血脂四项及血清同型半胱氨酸水平与急性脑梗死发生的相关性分析  

Correlation Analysis Between Levels of Four Serum Lipid Indexes Serum Homocysteine and Occurrence of Acute Cerebral Infarction in Patients with H-type Hypertension

作　　者：王俊珺[1] 王本孝[1] 唐永亮 施燕红[1] 王鹏[1] WANG Junjun;WANG benxiao;TANG Yongliang(Wanbei Coal Power Group General Hospital/the Third Affiliated Hospital of Bengbu Medical College,Anhui Suzhou 234011,China)

机构地区：[1]皖北煤电集团总医院/蚌埠医学院第三附属医院神经内科,安徽宿州234011

出　　处：《河北医学》2020年第7期1130-1133,共4页Hebei Medicine

基　　金：安徽省卫生厅资助基金项目,(编号:2015010315)。

摘　　要：目的:分析"H型"高血压患者血脂四项及血清同型半胱氨酸(Hcy)水平与急性脑梗死发生的相关性.方法:将我院2018年8月至2019年7月收治的80例"H型"高血压患者作为研究对象,根据其是否发生急性脑梗死将患者分为急性脑梗死组(n=30)和非急性脑梗死组(n=50),另选择同期于我院进行体检的40例健康人群作为对照组,对比三组一般资料和血脂四项[甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)及高密度脂蛋白(HDL-C)]和血清Hcy水平,分析"H型"高血压患者血脂四项及血清Hcy水平与急性脑梗死发生的相关性.结果:急性脑梗死组和非急性脑梗死组收缩压均高于对照组(P<0.05);急性脑梗死组血清TC、TG、LDL-C、Hcy水平均高于非急性脑梗死组(P<0.05),血清HDL-C水平低于非急性脑梗死组(P<0.05);血清TC、TG、LDL-C、Hcy水平与急性脑梗死发呈正相关(P<0.05),血清HDL-C水平与急性脑梗死发生呈负相关(P<0.05);血清TC、TG、HDL-C、LDL-C、Hcy是"H型"高血压患者发生急性脑梗死的影响因素(P<0.05).结论:"H型"高血压患者血脂四项及血清Hcy水平与急性脑梗死发生存在相关性,临床监测血脂四项、血清Hcy水平,对评估"H型"高血压患者急性脑梗死发生具有重要价值.Objective:To analyze the correlation between levels of four serum lipid indexes,serum homocysteine(Hcy)and occurrence of acute cerebral infarction(ACI)in patients with H-type hypertension.Methods:Eighty patients with H-type hypertension who were admitted to the hospital from August 2018 to July 2019 were enrolled as study objects.According to presence or absence of ACI,they were divided into ACI group(n=30)and non-ACI group(n=50).Another 40 healthy people after physical examination in the hospital during the same period were enrolled as control group.The general data,levels of four serum lipid indexes[triglyceride(TG),cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)]and serum Hcy were compared among the three groups.The correlation between levels of four serum lipid indexes,serum Hcy and occurrence of ACI in patients with H-type hypertension was analyzed.Results:The systolic blood pressure in ACI group and non-ACI group was higher than that in control group(P<0.05).Serum TC,TG,LDL-C and Hcy levels in ACI group were higher than those in non-ACI group(P<0.05),while serum HDL-C levels were lower than non-ACI group(P<0.05).Serum TC,TG,LDL-C and Hcy levels were positively correlated with the occurrence of ACI(P<0.05),while serum HDL-C level was negatively correlated with it(P<0.05).Serum TC,TG,HDL-C,LDL-C and Hcy were influencing factors of ACI in patients with H-type hypertension(P<0.05).Conclusion:There is correlation between levels of four serum lipid indexes,serum Hcy and occurrence of ACI in patients with H-type hypertension.Clinical monitoring on levels of four serum lipid indexes and serum Hcy is of important value for assessing occurrence of ACI in patients with H-type hypertension.

关 键 词："H型"高血压 血脂四项 同型半胱氨酸 急性脑梗死 

分 类 号：R544.1[医药卫生—心血管疾病] R743.33[医药卫生—内科学]