通窍鼻炎颗粒辅助治疗过敏性鼻炎的效果及对患者免疫功能的影响  

Effect of Tongqiao Biyan granule on allergic rhinitis and its impact on patients'immune function

作　　者：陈敏芬[1] 李小燕[1] 陈丹丹 徐发莹 CHEN Minfen;LI Xiaoyan;CHEN Dandan;XU Faying(Department of Otorhinolaryngology,Taizhou Hospital in Zhejiang Province,Linhai317000,China;Operation Department,Taizhou Hospital in Zhejiang Province,Linhai317000,China;School of Medical Imaging,Hangzhou Medical College,Hangzhou310053,China)

机构地区：[1]浙江省台州医院耳鼻咽喉科,浙江临海317000 [2]浙江省台州医院手术部,浙江临海317000 [3]杭州医学院医学影像学院,浙江杭州310053

出　　处：《中国现代医生》2020年第18期85-88,共4页China Modern Doctor

基　　金：浙江省自然科学基金(LY19H280009)。

摘　　要：目的探讨通窍鼻炎颗粒辅助治疗过敏性鼻炎(AR)的效果及对患者免疫功能的影响。方法选择我院2018年3月~2019年3月进行治疗的90例病历资料十分完整的AR患者作为研究对象,依据随机对照原则分为两组,每组45例。对照组接受常规西药治疗,观察组在此基础上加用通窍鼻炎颗粒。比较两组患者疗程结束后治疗效果、治疗前后症状评分、鼻腔生理功能指标[鼻腔阻力(NR)]、标记物[白细胞介素4(IL-4)、γ-干扰素(IFN-γ)]检测结果变化情况。结果疗程结束后观察组患者治疗总有效率明显高于对照组,差异有统计学意义(P<0.05);疗程结束后观察组鼻痒评分、鼻塞评分、喷嚏评分、流涕评分均明显低于对照组,差异有统计学意义(P<0.05);疗程结束后观察组NR、IL-4水平明显低于对照组,IFN-γ水平明显高于对照组,差异有统计学意义(P<0.05)。结论通窍鼻炎颗粒辅助治疗AR疗效显著,能够改善患者鼻腔生理功能和免疫功能,值得临床推荐。Objective To investigate the effect of Tongqiao Biyan granule on the adjuvant treatment of allergic rhinitis(AR)and its influence on the immune function of patients.Methods Ninety AR patients with complete medical records in our hospital from March 2018 to March 2019 were selected as the subjects of this study.They were divided into two groups based on the principle of randomized control,with 45 patients in each group.The control group received conventional western medicine treatment,and the observation group was supplemented with Tongqiao Biyan granule.The treatment effect after the treatment and detection results change of symptom scores,nasal physiological function indexes[nasal resistance(NR)],marker(IL-4),(IFN-γ)before and after treatment between the two groups were compared.Results After the treatment course,the total effective rate of the observation group was significantly higher than that of the control group(P<0.05).The nasal itching score,nasal congestion score,sneezing score and runny nose score of the observation group were significantly lower than those of the control group,and the difference was significant(P<0.05).The levels of NR and IL-4 in the observation group were significantly lower than those in the control group,and the levels of IFN-γwas significantly higher than that in the control group(P<0.05).Conclusion Tongqiao Biyan granule has significant effect on adjuvant treatment of AR and can improve the physiological and immune functions of patients'nasal cavity.It is worthy of clinical recommendation.

关 键 词：通窍鼻炎颗粒 过敏性鼻炎 效果 免疫功能 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]