孟鲁司特钠辅助治疗小儿毛细支气管炎临床疗效  

Clinical effect of montelukast sodium on the adjuvant treatment of bronchiolitis in children

作　　者：宁春艳 NING Chunyan(Department of Pediatrics,Third Hospital of Changsha,Hunan Province,Changsha 410000,China)

机构地区：[1]长沙市第三医院儿科,410000

出　　处：《临床合理用药杂志》2020年第19期29-31,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察孟鲁司特钠辅助治疗小儿毛细支气管炎的临床效果。方法选取2017年1月-2018年8月于长沙市第三医院儿科诊治的毛细支气管炎患儿100例,采用随机数字表法分为观察组和对照组各50例。对照组采用雾化吸入、抗病毒及止咳平喘等综合治疗,观察组在对照组治疗基础上给予孟鲁司特钠片治疗。比较2组患儿的临床疗效、临床各项症状体征改善时间及住院时间,治疗前后检测2组患儿血清白三烯B4水平和尿白三烯E4水平,比较2组患儿治疗期间不良反应发生情况,随访1年,比较2组患儿治疗后6个月、12个月喘息复发率。结果观察组患儿治疗总有效率为98.00%,高于对照组的84.00%(P<0.05);观察组患儿咳嗽、喘息、肺部喘鸣音改善时间及住院时间均明显短于对照组(P<0.01);治疗后,2组患儿血清白三烯B4水平和尿白三烯E4水平均低于治疗前,且观察组低于对照组(P<0.05);2组患儿治疗期间未发生严重不良反应;观察组患儿治疗后6个月、12个月喘息复发率均低于对照组(P<0.05)。结论在常规治疗基础上辅以孟鲁司特钠治疗小儿毛细支气管炎效果较好,可降低患儿血清白三烯B4水平和尿白三烯E4水平,且安全性较高,治疗后具有较好的远期效果,值得推荐。Objective To observe the clinical effect of montelukast sodium adjuvant treatment in children with bronchiolitis.Methods 100 children with bronchiolitis diagnosed and treated in the Department of Pediatric in the Third Hospital of Changsha from January 2017 to August 2018.Random number table method was divided into observation group and control group,each of 50 cases.The control group was treated with aerosol inhalation,antiviral,antitussive and antiasthmatic.The observation group was given montelukast sodium tablets based on the treatment of the control group.Compared the clinical efficacy,clinical symptoms and signs improvement time and hospital stay of the 2 groups of patients.Before and after treatment,serum leukotriene B4 level and urinary leukotriene E4 level were detected in 2 groups of patients.Compared the incidence of adverse reactions during treatment between the 2 groups of patients.Followed up for 1 year and compared the recurrence rates of wheezing at 6 months and 12 months after treatment in the 2 groups.Results The total effective rate of treatment in the observation group was 98.00%,which was higher than 84.00%in the control group(P<0.05).The improvement time of coughing,wheezing,lung wheezing in the observation group and hospitalization time were significantly shorter than that of the control group(P<0.01).After treatment,the levels of serum leukotriene B4 and urine leukotriene E4 in the 2 groups were lower than before treatment,and the observation group was lower than the control group(P<0.05).No serious adverse reactions occurred in the 2 groups of patients during treatment.The recurrence rate of wheezing in the observation group was lower than that in the control group at 6 and 12 months after treatment(P<0.05).Conclusion On the basis of conventional treatment,supplemented with montelukast sodium to treat children with bronchiolitis has a better effect,which can reduce the serum leukotriene B4 level and urinary leukotriene E4 level in patients,has higher safety and better treatment.The long-t

关 键 词：孟鲁司特钠 毛细支气管炎 小儿 白三烯 咳嗽 喘息 

分 类 号：R725.6[医药卫生—儿科]