高通量血液透析联合百令胶囊对糖尿病肾病血液透析患者氧化应激、微炎性状态及生存质量的影响  

Effect of high throughput hemodialysis combined with Bailing capsules on oxidative stress response,microinflammation and life quality of hemodialysis patients with diabetic nephropathy

作　　者：崔俊[1] 亢宁苏 周春霞[1] 陆建勋[1] 郑露[1] Cui Jun;Kang Ningsu;Zhou Chunxia;Lu Jianxun;Zheng Lu(Department of Nephrology, Nantong Third People's Hospital, Jiangsu Province,Nantong 226000,China)

机构地区：[1]江苏省南通市第三人民医院肾内科,226000

出　　处：《疑难病杂志》2020年第8期764-768,共5页Chinese Journal of Difficult and Complicated Cases

基　　金：江苏省自然科学基金青年科技人才专项资金资助项目(BK20162512)。

摘　　要：目的观察高通量血液透析联合百令胶囊对糖尿病肾病血液透析患者氧化应激、微炎性状态及生存质量的影响。方法选择2018年1—12月江苏省南通市第三人民医院肾内科收治糖尿病肾病血液透析患者100例作为研究对象。按照随机数字表法分为低透组(33例,低通量血液透析治疗)、高透组(33例,高通量血液透析治疗)及联合组(34例,高通量血液透析联合百令胶囊治疗),3组均治疗8周。比较3组治疗后的不良心血管事件发生情况和随访1年的生存情况,检测并比较3组患者治疗前后血清总蛋白(TP)、前白蛋白(PA)、白蛋白(ALB)、过氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)、高敏C反应蛋白(hs-CRP)、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平。结果联合组的不良心血管事件发生率明显低于低透组和高透组(χ^2/P=9.738/0.021),随访1年生存率明显高于低透组和高透组(χ^2/P=11.315/0.018)。治疗后,3组患者血清TP、PA、ALB、SOD、GSH-Px水平均高于治疗前,血清MDA水平均低于治疗前,且低透组、高透组、联合组上述指标的改善情况依次提高/降低(F/P=22.994/0.000、156.545/0.000、36.512/0.000、23.607/0.000、158.202/0.000、23.245/0.000);高透组及联合组血清hs-CRP、IL-6及TNF-α水平较治疗前降低,而低透组上述指标较治疗前升高,3组治疗后比较差异有统计学意义(F/P=388.173/0.000、121.384/0.000、194.367/0.000)。结论高通量血液透析联合百令胶囊治疗有助于改善糖尿病肾病血液透析患者的预后,能够降低不良心血管事件发生率并提高其短期生存率,提高生存质量,减轻糖尿病肾病血液透析患者体内的氧化应激反应和微炎性状态。Objective To observe the effect of high throughput hemodialysis combined with Bailing capsules on oxidative stress response,microinflammation and life quality of hemodialysis patients with diabetic nephropathy.Methods 100 hemodialysis patients with diabetic nephropathy who were admitted to Department of Nephrology in Nantong Third People's Hospital of Jiangsu Province from January 2018 to December 2019 were selected as research object,which divided into the low throughput hemodialysis group(33 cases,treated with low throughput hemodialysis),high throughput hemodialysis group(33 cases,treated with high throughput hemodialysis)and high throughput hemodialysis combined with Bailing capsules group(34 cases,treated with high throughput hemodialysis combined with Bailing capsules).The three groups were treated for 8 weeks.The incidence of adverse cardiovascular events and 1-year follow up survival were compared among the three groups.The levels of serum total protein(TP),prealbumin(PA),albumin(ALB),superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px),hypersensitive C reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)of the three groups before and after treatment were compared.The cardiovascular event rates and survival rates followed up for 1 year of the three groups after treatment were compared.Results The cardiovascular event rate of the high throughput hemodialysis combined with Bailing capsules group after treatment were significantly lower than that of the low throughput hemodialysis group and high throughput hemodialysis group(χ^2/P=9.738/0.021),the survival rate followed up for 1 year were significantly higher than that of the low throughput hemodialysis group and high throughput hemodialysis group(χ^2/P=11.315/0.018).After treatment,The levels of serum TP,PA,ALB,SOD,GSH-Px of the three groups were higher than those before treatment,the levels of serum MDA of the three groups after treatment were lower than those before treatment,and the improvement of the a

关 键 词：糖尿病肾病 血液透析 高通量 百令胶囊 氧化应激 微炎性反应 生存质量 

分 类 号：R47[医药卫生—护理学]