青年女性肝豆状核变性患者驱铜治疗前后性激素水平变化  

Changes of sex hormone levels in young women with Wilson's disease before and after copper removal treatement

作　　者：高伟明 王文斌 胡文彬 陈林 王佳炜 朱玉龙 朱凌 童广安 严彦 吴君霞 Gao Weiming;Wang Wenbin;Hu Wenbin;Chen Lin;Wang Jiawei;Zhu Yulong;Zhu Ling;Tong Guang’an;Yan Yan;Wu Junxia(Affiliated Hospital of Institute of Neurology, Anhui College of Traditional Chinese Medicine, Hefei 230061,China)

机构地区：[1]安徽中医药大学神经病学研究所附属医院神经内科,230061 [2]安徽中医药大学神经病学研究所

出　　处：《疑难病杂志》2020年第8期795-798,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金资助项目(81473535);安徽中医药大学科研项目基金资助(2014lckf02016)。

摘　　要：目的观察青年女性肝豆状核变性(WD)患者驱铜治疗前后性激素水平的变化。方法收集2014年6月—2017年12月安徽中医药大学神经病学研究所附属医院神经内科诊治青年女性WD患者33例作为病例组,另选择30例健康者作为健康对照组,病例组患者先后予以二巯丙磺酸钠及青霉胺驱铜,采用放射免疫法测定病例组驱铜前后及健康对照组血清性激素水平,比较2组性激素水平的变化。结果与健康对照组比较,WD病例组整个治疗过程雌二醇(E2)、促黄体生成素(LH)、孕酮(PGN)、睾酮(TTE)、泌乳素(PRL)均升高,卵泡刺激素(FSH)均降低(P<0.05);与驱铜治疗前比较,短期驱铜后E2、FSH、LH、PGN均升高,TTE、PRL降低(P<0.05);与短期驱铜治疗后比较,驱铜治疗1年后E2、LH、PGN降低(P<0.01)。治疗中未出现严重不良反应。结论青年女性WD患者有多项性激素水平异常,长期、有效的驱铜治疗,能够使其显著改善。Objective To observe the changes of sex hormone levels in young women with Wilson's disease(WD)before and after copper removal.Methods From June 2014 to December 2017,33 young female patients with WD were selected as case group.Another 30 healthy subjects were selected as the control group.The patients in the case group were given sodium Dimercaptopropanesulfonate and penicillamine successively.Radioimmunoassay was used to measure the serum sex hormone levels of the two groups before and after copper removal.Results Compared with the healthy control group,estradiol(E2),luteinizing hormone(LH),progesterone(PGN),testosterone(TTE)and prolactin(PRL)were all increased,while follicle stimulating hormone(FSH)was decreased(P<0.05)in the WD case group during the whole treatment process;compared with the before copper removal treatment,E2,FSH,LH and PGN were all increased,TTE and PRL were decreased(P<0.05)after short-term copper removal;Compared with the short-term treatment,E2,LH and PGN decreased 1 year later(P<0.01).There were no serious adverse reactions in the treatment.Conclusion There are many abnormal sex hormone levels in young women with WD.Long term and effective copper removal treatment can significantly improve it.

关 键 词：Wilson病 性激素 二巯丙磺酸钠 青年女性 

分 类 号：R71[医药卫生—妇产科学]