急性心肌梗死患者血清白细胞介素16及和肽素检测的临床意义  

Clinical significance of serum IL-16 and copeptin in patients with acute myocardial infarction

作　　者：刘冰[1] 杨帅[1] 赵岩 魏志斌[1] LIU Bing;YANG Shuai;ZHAO Yan;WEI Zhibin(Department of Laboratory Medicine,Tianjin Baodi District People􀆳s Hospital,Tianjin 301800;Department of Laboratory Medicine,First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 301800,China)

机构地区：[1]天津市宝坻区人民医院检验科,天津市301800 [2]天津市中医药大学第一附属医院检验科,天津市301800

出　　处：《中国动脉硬化杂志》2020年第8期711-715,共5页Chinese Journal of Arteriosclerosis

基　　金：天津市科技发展指导性计划(TJSW2016021)。

摘　　要：目的探讨急性心肌梗死(AMI)患者血清白细胞介素16(IL-16)及和肽素(Copeptin)的表达及其临床意义。方法选取AMI患者108例,根据心电图检查结果是否出现ST段抬高将患者分为急性ST段抬高型心肌梗死(STEMI)组(55例)和急性非ST段抬高型心肌梗死(NSTEMI)组(53例)。另选取同期在行体检的健康志愿者50例作为对照组。检测三组研究对象血清IL-16、Copeptin、肿瘤坏死因子α(TNF-α)、IL-18、高敏C反应蛋白(hs-CRP)、N端脑钠肽前体(NT-proBNP)、肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)的水平。结果STEMI组患者的血清IL-16、Copeptin、TNF-α、IL-18、hs-CRP、NT-proBNP、CK-MB、cTnI水平均高于NSTEMI组和对照组,差异均有统计学意义(P<0.05),NSTEMI组患者的血清IL-16、Copeptin、TNF-α、IL-18、hs-CRP、NT-proBNP、CK-MB、cTnI水平均高于对照组,差异均有统计学意义(P<0.05)。Logistic回归分析显示,AMI患者血清IL-16与TNF-α、hs-CRP、NT-proBNP、CK-MB、cTnI有密切的影响关系(P<0.05);AMI患者血清Copeptin与hs-CRP、NT-proBNP、CK-MB、cTnI有密切的影响关系(P<0.05)。结论AMI患者血清IL-16、Copeptin水平明显升高,且与其他炎症因子及心肌标志物的表达密切相关,由于血清样本获取方便,且检测方法简单易行,临床可通过检测AMI患者血清IL-16、Copeptin水平来获取更多的诊疗信息。Aim To investigate the expression of serum interleukin-16(IL-16)and copeptin in patients with acute myocardial infarction(AMI)and its clinical significance.Methods 108 patients with AMI were enrolled.The patients were divided into acute ST-segment elevation myocardial infarction(STEMI)group(55 cases)and acute non-ST-segment elevation myocardial infarction(NSTEMI)group(53 cases)according to the ECG results.Another 50 healthy volunteers who underwent physical examination were selected as the control group.Serum IL-16,copeptin,tumor necrosis factor alpha(TNF-α),IL-18,high sensitivity C-reactive protein(hs-CRP),N-terminal pro-brain natriuretic peptide(NT-proBNP),creatine kinase isoenzyme(CK-MB)and cardiac troponin I(cTnI)were detected in three groups.Results The levels of serum IL-16,copeptin,TNF-α,IL-18,hs-CRP,NT-proBNP,CK-MB and cTnI in the STEMI group were higher than those in the NSTEMI group and the control group,and the differences were statistically significant(P<0.05).The levels of serum IL-16,copeptin,TNF-α,IL-18,hs-CRP,NT-proBNP,CK-MB and cTnI in the NSTEMI group were higher than those in the control group,the differences were statistically significant(P<0.05).Logistic regression analysis showed that serum IL-16 had a close relationship with TNF-α,hs-CRP,NT-proBNP,CK-MB and cTnI in AMI patients(P<0.05).Serum copeptin had a close relationship with hs-CRP,NT-proBNP,CK-MB and cTnI in patients with AMI(P<0.05).Conclusions The levels of serum IL-16 and copeptin in patients with AMI are significantly increased,and they are closely related to the expression of some inflammatory factors and myocardial markers.It is easy to obtain serum samples,and the detection method is simple.Clinical information can be obtained by detecting the levels of IL-16 and copeptin in serum of patients with AMI.

关 键 词：急性心肌梗死 白细胞介素16 和肽素 炎性因子 心肌标志物 

分 类 号：R542.22[医药卫生—心血管疾病]