纳米柠檬酸铁脂质体的体外降解及释放研究  

Degradation and Release Study of Nano-ferric Citrate Liposomes

作　　者：耿丽娜[1] 张茹 李文新[1] 孙凯玥 郝振芳[1] GENG Lina;ZHANG Ru;LI Wenxin;SUN Kaiyue;HAO Zhenfang(College of Chemistry and Material Science,Hebei Normal University,Hebei Shijiazhuang 050024,China)

机构地区：[1]河北师范大学化学与材料科学学院,河北石家庄050024

出　　处：《河北师范大学学报（自然科学版）》2020年第3期243-250,共8页Journal of Hebei Normal University：Natural Science

基　　金：国家自然科学基金(31201305);河北省自然科学基金(B2019205054)。

摘　　要：采用薄膜旋转蒸发-超声法制备了纳米柠檬酸铁脂质体(FAC-Lip).探究了光照、温度、pH对FAC-Lip降解的影响,采用零级动力学和一级动力学模型判断降解模型,计算出半衰期(t1/2)和降解速率常数(k);采用透析法测定了FAC-Lip和游离柠檬酸铁(Free-FAC)在模拟胃液中的稳定性和血浆中的释放情况.结果表明:FAC-Lip的降解符合一级动力学模型,光照、高温、pH过低或过高都会加速FAC-Lip的降解;在模拟胃液中FAC-Lip具有缓释性,且比Free-FAC稳定性好;在血浆中FAC-Lip也具有缓释性,降解属于双相动力学模型.Ferric citrate liposome(FAC-Lip) was prepared using a rotary-evaporated film-ultrasonication method.The effects of light,temperature,and pH on the degradation of FAC-Lip were explored.Zero-and first-order kinetic models were used to determine the degradation model,both half-life(t1/2) and degradation rate constant(k) were calculated.The stability of FAC-Lip and free ferric citrate(Free-FAC) in simulated gastric fluid and plasma were determined by dialysis method.The results showed that the degradation of FAC-Lip conformed to the first-order kinetic model,and the degradation of FAC-Lip would be accelerated when it was exposed to light,high temperature,low or high pH,respectively.FAC-Lip in simulated gastric juice was sustained release and had better stability than Free-FAC.FAC-Lip was also sustained release in plasma and belong to a biphasic kinetic model.

关 键 词：柠檬酸铁脂质体 稳定性 降解动力学 体外释放 释放模型 

分 类 号：O642.1[理学—物理化学]