清及清以前桃核承气汤配伍的数据分析  

Compatibility Data Analysis of Taoren and Guizhi in Taohe Chengqi Decoction in Qing Dynasty and before Qing Dynasty

作　　者：宋慧荣[1] 杨学琴[1] 罗亚敏[1] 高明慧 李冉 陶晓华[1] SONG Hui-rong;YANG Xue-qin;LUO Ya-min;GAO Ming-hui;LI Ran;TAO Xiao-hua(Beijing University of Traditional Chinese Medicine,Beijing 100029,China)

机构地区：[1]北京中医药大学,北京100029

出　　处：《中国中医基础医学杂志》2020年第7期977-980,985,共5页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：中央高校基本科研业务费项目(2018-JYBZZ-XS043)-桃核承气汤桃仁、桂枝应用规律研究;国家“重大新药创制”科技重大专项(2018ZX09721005-007-009)-经典名方桃核承气汤复方颗粒研究开发。

摘　　要：目的:分析清及清以前文献记载桃核承气汤中桃仁、桂枝配伍的特点,为临床应用桃核承气汤的药物用量和配伍提供参考。方法:利用电子和手工相结合的检索方式,并按照纳入标准搜集清及清以前桃核承气汤相关文献,归纳整理方药,统一桃仁、桂枝的用量单位,并建立数据库统计分析用量配比及数据特点。结果:按照纳入标准共检出方剂100首,桃仁、桂枝比例r<0.5有52首,其中治疗伤寒蓄血证41首占79%;0.5≤r≤1有23首,其中治疗伤寒蓄血证16首占70%;r>1有25首,疾病科属分布大体均匀,且治疗肝胆蓄血证者全在此范围内。在不同疾病科属的桃仁、桂枝比例两两比较中,伤寒蓄血分别与肝胆蓄血、温病蓄血的两两比较差异有统计学意义。结论:运用桃核承气汤治疗伤寒蓄血与肝胆蓄血、温病蓄血两类蓄血疾病时的桃仁、桂枝比例有明显差别,采用统计学方法分析桃核承气汤桃仁、桂枝的配伍数据及应用,可为临床合理用药提供借鉴。Objective:To analyze the characteristics of the compatibility of Taoren and Guizhi in Taohe Chengqi Decoction recorded in the Qing Dynasty and before,so as to provide reference for the clinical application of Taohe Chengqi Decoction.Method:Use the combination of electronic and manual search methods and collect relevant documents of Taohe Chengqi Decoction from Qing Dynasty and before according to the inclusion criteria,summarize and formulate prescriptions,unify the dosage units of Taoren and Guizhi,establish a database,and statistical analysis of usage ratio and data characteristics.Results:A total of 100 prescriptions were detected according to the inclusion criteria,and the ratio of Taoren and Guizhi r was less than 0.5 with 52,of which 41 were treated for Shanghan and blood accumulation,accounting for 79%;0.5≤r≤1 was 23,and 16 were treated for typhoid fever and blood accumulation accounted for 70%;and r>1there were 25,the distribution of disease families was generally even,and all the patients with hepatobiliary blood storage syndrome were within this range.In the pairwise comparison of the proportions of Taoren and Guizhi of different disease families,Shanghan blood storage was statistically significant compared with hepatobiliary blood storage and warm disease blood storage.Conclusion:Taohe Chengqi Decoction has significant differences in the proportion of Taoren Guizhi in the treatment of Shanghan blood storage,hepatobiliary blood storage,warmth blood storage and warm blood storage.The compatibility data and application of Guizhi can provide a reference for rational clinical medication.

关 键 词：桃核承气汤 桃仁 桂枝 配伍 

分 类 号：R289.5[医药卫生—方剂学]