早卵泡期长效长方案与拮抗剂方案用于高龄多囊卵巢助孕效果比较  

The application efficacy of long-acting long-term regimen in early follicular phase and antagonist regimen for treating elderly women with polycystic ovarian syndrome

作　　者：刘文霞[1] 王碧君 刘曼曼[1] 管一春[1] 杜明泽 王兴玲[1] LIU Wenxia;WANG Bijun;LIU Manman;GUAN Yichun;DU Mingze;WANG Xingling(The Third Affiliated Hospital of Zhengzhou University, Zhengzhou,Henan Province, 450000)

机构地区：[1]郑州大学第三附属医院,450000

出　　处：《中国计划生育学杂志》2020年第6期908-911,共4页Chinese Journal of Family Planning

摘　　要：目的:探究早卵泡期长效长方案与促性腺激素释放激素拮抗剂(GnRH-A)方案对高龄多囊卵巢(PCOS)患者的治疗效果。方法:回顾性收集2017年1月-2018年1月在本院行体外受精-胚胎移植(IVF-ET)助孕的高龄PCOS患者120例临床资料,其中采用早卵泡期长效长方案治疗为早卵泡长方案组60例,GnRH-A方案治疗为拮抗剂组60例。观察两组Gn启动日及HCG扳机日卵泡刺激素(FSH)、黄体生成素(LH)及雌二醇(E2)水平,生化指标及临床结局。结果:拮抗剂组Gn用药时间(10.7±2.1d)及用药量(1287.23±552.21U)均少于早卵泡长方案组(15.8±2.6d、1627.23±582.80U),优质胚胎数(7.3±2.1个)高于早卵泡长方案组(4.1±1.7个)、中重度OHSS发生率(0)低于早卵泡长方案组(10.0%)(均P<0.05)。结论:高龄PCOS患者应用GnRH-A方案进行IVF-ET与传统的早卵泡期长效长方案有着相近的激素调节及促排作用,但能缩短治疗时间及Gn用药量,改善IVF-ET妊娠结局,降低OHSS发生率。Objective:To explore the therapeutic effect of long-acting long-term regimen in early follicular phase or gonadotropin-releasing hormone antagonist(GnRH-A)regimen for treating elderly women with polycystic ovarian syndrome(PCOS).Methods:The clinical data of 120 elderly women with PCOS who underwent in vitro fertilization-embryo transfer(IVF-ET)from January 2016 to January 2018 were collected retrospectively,and these women were divided into two groups(60 cases in each group).The women in group A were given long-acting long-term regimen,and the women in group B were given GnRH-A regimen.The levels of follicle stimulating hormone(FSH),luteinizing hormone(LH),and serum estradiol(E 2)of women on the day of Gn started up and on the chorionic gonadotropin(HCG)trigger day in both groups were measured.And biochemical indexes and clinical outcomes of women were compared between the two groups.Results:The time and dosage of Gn administration,and rate of moderate to severe OHSS occurrence of women in group B were 10.7±2.1d,1287.23±552.21u,and 0.0%,respectively,which were significant lower than those(15.8±2.6d,627.23±582.80u,and 10.0%,respectively)of women in group A,but the number of high-quality embryos of women in group B was 7.3±2.1,which was significant higher than that(4.1±1.7)of women in group A(all P<0.05).Conclusion:GnRH-A regimen for treating elderly women with PCOS who receive IVF-ET has the similar effect of long-acting long-term regimen for regulating hormone and stimulating ovulation in early follicular phase,but which can shorten the treatment time,reduce Gn dose,improve pregnancy outcomes after IVF-ET,and reduce the incidence of OHSS.

关 键 词：高龄多囊卵巢 体外受精-胚胎移植 早卵泡期长效长方案 促性腺激素释放激素拮抗剂方案 临床效果 

分 类 号：R714.8[医药卫生—妇产科学]