克罗米芬联用黄体酮和戊酸雌二醇治疗多囊卵巢综合征不孕效果  

Effect of clomiphene combined with progesterone for treating infertile women caused by polycystic ovary syndrome

作　　者：刘淑玉[1] 郑轶[1] 张兰玲[1] 周玉[1] LIU Shuyu;ZHENG Yi;ZHANG Lanling;ZHOU Yu(The First Affiliated Hospital of Bengbu Medical College, Anhui Province,233000)

机构地区：[1]蚌埠医学院第一附属医院,233000

出　　处：《中国计划生育学杂志》2020年第5期726-729,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨克罗米芬联合黄体酮和戊酸雌二醇治疗多囊卵巢综合征(PCOS)不孕的临床疗效及对卵巢功能的影响。方法:选取本院收治的100例PCOS不孕症患者,随机分为对照组(50例)单用克罗米芬,联合组(50例)克罗米芬联合黄体酮和戊酸雌二醇,对比两组临床疗效。结果:治疗后,联合组子宫内膜厚度值、成熟卵泡个数、最大卵泡直径均大于对照组,HMG用量、平均治疗周期均短于对照组(P<0.05)。与治疗前相比,两组HCG日的睾酮(T)、黄体生成素(LH)/卵泡刺激素(FSH)水平均降低,雌二醇(E2)水平升高(P<0.05),且联合组HCG日的E2水平高于对照组(P<0.05)。联合组临床妊娠率(56.0%)及治疗总有效率(88.0%)高于对照组(28.0%、66.0%)(P<0.05),两组排卵率、流产率、多胎妊娠率及不良反应发生率无差异(P>0.05)。结论:克罗米芬联合黄体酮和戊酸雌二醇治疗PCOS不孕症,能够有效促进子宫内膜增厚,减少尿促性腺素用量,改善卵巢功能,提高临床妊娠率。Objective:To investigate the clinical efficacy of clomiphene combined with progesterone for treating infertile women caused by polycystic ovary syndrome(PCOS),and to study its effect on ovarian function of women.Methods:100 infertile women caused by PCOS were divided into two groups(50 cases in each group).The women in the control group were treated by clomiphene alone,and the women in the study group were treated by clomiphene combined with progesterone.The clinical efficacy of women was compared between the two groups.Results:After treatment,the endometrial thickness,the number of mature follicles,and the diameter of the largest follicles of women in the study group were significant higher than those of women in the control group,but the HMG dosage and the average treatment period of women in the study group were significant less(P<0.05).Compared with those before treatment,the T level and value of LH/FSH on HCG day of women in both groups had decreased significantly,but the E2 level had increased significantly(P<0.05).After treatment,the E2 level on HCG day of women in the study group was significant higher than that of women in the control group(P<0.05).The clinical pregnancy rate and the total effective rate of treatment of women in the study group were 56.0%and 88.0%,which were significant higher than those(28.0%and 66.0%)of women in the control group(P<0.05).There were no significant difference in the ovulation rate,abortion rate,multiple pregnancy rate,and the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Clomiphene combined with progesterone for treating infertile women caused by PCOS can promote endometrial thickening effectively,can reduce the dosage of gonadotropin used,can improve ovarian function,and can increase clinical pregnancy rate.

关 键 词：多囊卵巢综合征 不孕症 黄体酮 克罗米芬 戊酸雌二醇 临床疗效 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]