超声颅内透明层联合血清AFP、Freeβ-hCG诊断胎儿神经管畸形价值  

The value of fetal intracranial hyaline layer by ultrasonography combined with serum AFP and freeβ-hCG levels detection of pregnant women for diagnosing fetal neural tube malformation

作　　者：张理玲[1] 李亚敏[1] ZHANG Liling;LI Yamin(Puyang People's Hospital, Henan Province, 457000)

机构地区：[1]河南省濮阳市人民医院,457000

出　　处：《中国计划生育学杂志》2020年第5期739-742,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨超声颅内透明层、甲胎蛋白(AFP)及游离绒毛膜促性腺激素(Freeβ-hCG)联合检测在产前胎儿神经管畸形诊断中的应用价值。方法:收集2017年2月-2018年4月在本院产前检查及转诊最终确诊的神经管畸形胎儿孕妇52例为神经管畸形组,同期本院分娩健康胎儿的孕妇222例为正常组。比较两组血清AFP、Freeβ-hCG水平;以胎儿随访/尸检结果为金标准,分析超声颅内透明层、血清AFP、Freeβ-hCG及三者联合诊断神经管畸形效能。结果:神经管畸形组血清AFP、Freeβ-hCG的MoM值均高于正常组(P<0.05);超声颅内透明层、血清AFP、Freeβ-hCG联合检测诊断神经管畸形灵敏度(98.1%)高于血清AFP(78.9%)、Freeβ-hCG(75.0%)(P<0.05),特异度(97.8%)高于超声颅内透明层(87.8%)、血清AFP(78.4%)、Freeβ-hCG(75.7%)(P<0.05),准确度(97.8%)高于超声颅内透明层(88.7%)、血清AFP(78.5%)、Freeβ-hCG(75.6%)(P<0.05)。结论:超声颅内透明层、血清AFP、Freeβ-hCG检测均对胎儿产前神经管畸形有一定诊断价值,三者联合可提高诊断效能。Objective:To investigate the value of fetal intracranial hyaline layer by ultrasonography combined with serum alpha fetoprotein(AFP)and freeβsubunit of human chorionic gonadotropin(fβ-hCG)levels detection of pregnant women for diagnosing fetal neural tube malformation.Methods:From February 2017 to April 2018,52 pregnant women with fetal neural tube malformations were selected in study group,and 222 normal pregnant women were included in control group.The levels of serum AFP and fβ-hCG were compared between the two groups.Based on the results of fetal follow-up and autopsy as the gold standard,the value of fetal intracranial hyaline layer by ultrasonography combined with serum AFP and fβ-hCG levels detection for diagnosing fetal neural tube malformation were analyzed.Results:The MoM values of serum AFP and fβ-hCG levels in the study group were significant higher than those in the control group(P<0.05).The sensitivity of fetal intracranial hyaline layer by ultrasonography combined with serum AFP and levels for diagnosing fetal neural tube malformation was 98.1%,which was siginificant higher than that(78.9%)of serum AFP level or that(75.0%)of serum fβ-hCG level.The specificity of diagnosis of combination fetal intracranial hyaline layer by ultrasonography and levels of serum AFP and fβ-hCG was 97.8%,which was siginificant higher than that(87.8%)of fetal intracranial hyaline layer by ultrasonography only,that(78.4%)of AFP level only,or that(75.7%)of serum freeβ-hCG level only.And the accuracy of diagnosis of combination fetal intracranial hyaline layer by ultrasonography and levels of serum AFP and fβ-hCG was 97.8%,which was siginificant higher than that(88.7%)of fetal intracranial hyaline layer by ultrasonography,that(78.5%)of AFP level,or that(75.6%)of serum fβ-hCG level.Conclusion:The fetal intracranial hyaline layer by ultrasonography examination,the serum AFP level,or fβ-hCG level detection all have certain values for diagnosing fetal neural tube malformation,but combination diagnosis of them can effe

关 键 词：神经管畸形 超声 颅内透明层 甲胎蛋白 游离绒毛膜促性腺激素 诊断价值 

分 类 号：R445.1[医药卫生—影像医学与核医学] R714.5[医药卫生—诊断学]