吸入激素联合噻托溴铵治疗哮喘-慢阻肺重叠综合征的效果分析  

Analysis of the Effect of Inhaled Hormone Combined with Tiotropium Bromide on Asthma-coronary Obstruction Syndrome

作　　者：李浩 LI Hao(Department of Respiratory and Critical Care Medicine,Zhangzhou Hospital,Fujian Medical University,Zhangzhou,Fujian Province,363000 China)

机构地区：[1]福建医科大学附属漳州市医院呼吸与危重症医学科,福建漳州363000

出　　处：《中外医疗》2020年第16期10-12,共3页China & Foreign Medical Treatment

摘　　要：目的探讨哮喘-慢阻肺重叠综合征(ACOS)患者联用吸入激素与噻托溴铵的临床效果。方法该研究方便选取2015年12月—2018年6月期间就诊的66例ACOS患者,以随机数字表法将其分入研究组、对照组两组,两组患者例数相同。对照组仅用吸入激素进行治疗,研究组加用噻托溴铵。对比两组的发作周期、治疗后的肺功能指标、并发症发生率、临床疗效、用药不良反应等指标。结果研究组具有93.94%的治疗总有效率,比对照组的75.76%高,差异有统计学意义(χ^2=4.243,P=0.039<0.05)。研究组治疗后的发作周期为(9.43±2.46)d,比对照组的(5.23±0.45)d长,差异有统计学意义(t=9.648,P=0.000<0.05)。研究组并发症发生率为6.06%,低于对照组的30.30%,差异有统计学意义(χ^2=6.519,P=0.011<0.05)。两组用药不良反应率相近,差异无统计学意义(χ^2=1.015,P=0.314>0.05)。此外,研究组治疗后的肺功能指标吸气分数、1秒用力呼气量分别为(49.22±4.43)%和(1.98±0.65)L,均比对照组的(39.19±3.37)%和(1.19±0.35)L高,而残总比为(28.08±2.66)%,则比对照组的(39.56±3.34)%低,差异有统计学意义(t=10.352、6.147、15.485,P<0.05)。结论为ACOS患者联用吸入激素、噻托溴铵可比单用吸入激素更有效地改善肺功能、延后发作,同时不必担心严重并发症发生。Objective To observe the clinical effect of combined inhaled hormone and tiotropium bromide in patients with asthma-coronary obstruction syndrome(ACOS).Methods In this study,66 ACOS patients who were convenient treated from December 2015 to June 2018 were randomly divided into study group and control group.The number of patients in the two groups was the same.The control group was treated with inhaled hormones only,and the study group was treated with tiotropium bromide.The two groups were compared for their seizure cycle,pulmonary function indexes,complication rate,clinical efficacy,and adverse drug reactions.Results The total effective rate of treatment in the study group was 93.94%,which was higher than 75.76%in the control group.The difference was statistically significant(χ^2=4.243,P=0.039<0.05).The attack period in the study group after treatment was(9.43±2.46)d,which was longer than the control group(5.23±0.45)d,and the difference was statistically significant(t=9.648,P=0.000<0.05).The incidence of complications in the study group was 6.06%,which was lower than the control group's 30.30%,and the difference was statistically significant(χ^2=6.519,P=0.011<0.05).The adverse drug reaction rates between the two groups were similar,and the difference was not statistically significant(χ^2=1.015,P=0.314>0.05).In addition,the lung function index inspiratory fraction and forced expiratory volume in 1 second of the study group were(49.22±4.43)%and(1.98±0.65)L,respectively,which were both(39.19±3.37)%and(1.19±0.35)L,and the total residual ratio was(28.08±2.66)%,lower than(39.56±3.34)%of the control group,and the difference is statistically significant(t=10.352,6.147,15.485,P<0.05).Conclusion The combined use of inhaled hormone and tiotropium in patients with ACOS can improve lung function and delay seizures more than inhaled hormone alone,without worrying about serious complications.

关 键 词：哮喘-慢阻肺重叠综合征 噻托溴铵 吸入激素 联合 治疗效果 

分 类 号：R473[医药卫生—护理学]