加味逍遥汤治疗乳腺癌术后化疗副作用的临床观察  

Clinical Observation of Modified Xiaoyao Decoction in the Treatment of Breast Cancer after Postoperative Chemotherapy

作　　者：贾润霞[1] 董旭辉[1] 刘明[1] JIA Runxia;DONG Xuhui;LIU Ming(The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine,Henan Zhengzhou 45000,China)

机构地区：[1]河南中医药大学第三附属医院,河南郑州450000

出　　处：《中医药临床杂志》2020年第7期1326-1329,共4页Clinical Journal of Traditional Chinese Medicine

摘　　要：目的:观察运用加味逍遥汤治疗乳腺癌术后化疗副作用的临床疗效,总结临床经验。方法:选取2015年3月到2017年3月我院收治的乳腺癌术后化疗的患者共计63例,随机分为观察组33例与对照组30例,对照组采用CEF方案进行化疗,观察组在对照组治疗的基础上加用加味逍遥汤治疗,观察两组患者治疗前后总有效率、骨髓抑制、生存质量及不良反应。结果:治疗后,观察组总有效率78.79%,高于对照组53.33%(P<0.05);两组治疗前白细胞和血小板无差异性(P>0.05),治疗后两组白细胞和血小板均不同程度减少(P<0.05),观察组减少程度低于对照组(P<0.05);两组患者治疗前生存质量卡氏评分无差异性(P>0.05),两组治疗后较治疗前,差异有统计学意义(P<0.05),两组治疗后卡氏评分比较,差异有统计学意义(P<0.05),观察组明显优于对照组;观察组在恶心呕吐、便秘或腹泻及食欲不振等不良反应事件,比例均低于对照组,观察组优于对照组(P<0.05)。结论:加味逍遥汤治疗乳腺癌术后化疗副作用的临床疗效显著,能有效改善骨髓抑制,提高患者生存质量,减轻化疗后副反应,值得临床推广。Objective:To observe the clinical efficacy of modified Xiaoyao decoction in treating side effects of postoperative chemotherapy for breast cancer and to summarize clinical experience.Methods:A total of 63 patients undergoing postoperative chemotherapy for breast cancer admitted to our hospital from March 2015 to March 2017 were randomly divided into an observation group of 33 cases and a control group of 30 cases.The control group received chemotherapy using the CEF regimen.The observation group Based on the treatment of the control group,modified Xiaoyao decoction was added to observe the total effective rate,bone marrow suppression,quality of life and adverse reactions of the two groups of patients before and after treatment.Results:After treatment,the total effective rate of the observation group was 78.79%,higher than that of the control group by 53.33%(P<0.05);there was no difference in white blood cells and platelets before treatment between the two groups(P>0.05),and the two groups were different after treatment.The degree of reduction(P<0.05),the degree of reduction in the observation group was lower than that of the control group(P<0.05);there was no difference in the quality of life of the two groups of patients before treatment(P>0.05),the difference between the two groups after treatment was more than before treatment It was statistically significant(P<0.05),the difference between the two groups after the treatment of the Carr’s score was statistically significant(P<0.05),the observation group was significantly better than the control group;the observation group had nausea,vomiting,constipation or diarrhea and loss of appetite The proportion of other adverse events was lower than that of the control group,and the observation group was superior to the control group(P<0.05).Conclusion:Modified Xiaoyao decoction has significant clinical effect on the side effects of postoperative chemotherapy for breast cancer.It can effectively improve bone marrow suppression,improve the quality of life of patients,an

关 键 词：乳腺癌 术后化疗 加味逍遥汤 

分 类 号：R273[医药卫生—中西医结合]