广州市HPV疫苗上市后接种实施及人群接种状况初步分析  

Preliminary analysis on the post-marketing situation of implement of HPV vaccines and vaccinated population in Guangzhou

作　　者：云雪霞[1] 王大虎[1] 谭慧峰[1] 许建雄[1] 倪莉红[1] YUN Xuexia;WANG Dahu;TAN Huifeng;XU Jianxiong;NI LIhong(Guangzhou Center for Disease Control and Prevention,Guangdong 510440,China)

机构地区：[1]广州市疾病预防控制中心,广州510440

出　　处：《医学动物防制》2020年第8期787-791,共5页Journal of Medical Pest Control

基　　金：广州市科技计划资金资助项目(201904010025)。

摘　　要：目的了解广州市HPV疫苗上市后接种工作的开展实施、人群接种状况、疫苗安全性等基本情况。方法采用描述性流行病学方法,分析各价HPV疫苗上市以来疫苗采购及供应情况、接种门诊的设置、人群接种状况、疑似预防接种异常反应监测等情况。结果HPV疫苗上市后供应缺口较大,2018-2019年缺苗情况逐月加重,2019年上半年四价疫苗缺苗即达到43万余剂次、九价疫苗缺苗59万余剂次,二价疫苗相对充足。相比2018年上半年,2019年上半年各价疫苗接种总量上升121.53%,而二价疫苗接种量下降15.48%;天河区、海珠区、白云区、番禺区4个区接种量较大,合计占全市总接种量的60%以上。全市绝大部分的预防接种门诊及成人接种门诊可以接种。各价HPV疫苗接种后疑似预防接种异常反应发生率与全市监测平台的所有疫苗全年平均水平相比略低或无明显差异。结论广州市适龄妇女对HPV疫苗接种需求较大,人群接种量逐年增长迅速,但疫苗供应不足、人群对二价疫苗认知有偏差等导致特别是九价疫苗远不能满足人群接种需求,有待于不断提高市场供应及人群对疫苗的知晓率;各价HPV疫苗接种人群中监测安全性良好,提倡适龄人群尽早开展接种。Objective To master the post-marketing conditions of HPV vaccines in Guangzhou,including the status of vaccination efforts,vaccinated population and the safety of HPV vaccines.Methods The descriptive epidemiology method was used to analyze the post-marketing conditions relevant to HPV vaccines,including the situation of purchase and supply,the setting of immunization clinics,the status of vaccinated population and the occurrence of adverse event following immunization(AEFI).Results The supply gap of HPV vaccines was huge,and the shortage of vaccine got worse month by month in 2018-2019.The first half of 2019 faced a shortage of more than 430000 tetravalent HPV vaccines and 5900009-valent HPV vaccines,while the bivalent HPV vaccines were relatively sufficient.The total vaccination rose by 121.53%in the first half of 2019 compared with that in the first half of 2018,and the vaccination of bivalent HPV vaccines declined by 15.48%.The vaccination was mainly concentrated on Tianhe District,Haizhu District,Baiyun District and Panyu District,which accounted for more than 60%of the total vaccination.People can be vaccinated in most of the prophylactic vaccination clinics and adult vaccination clinics.The AEFI incidence rate was slightly lower or without significant differences compared with the coverage of all vaccines monitored in the whole city.Conclusion There was high demand of HPV vaccine in the group of right age,and the vaccination rate increased rapidly year by year.However,it was difficult to meet the demand,especially the demand of 9-valent HPV vaccine,because of the undersupply of vaccines and public misunderstanding about bivalent vaccine.Therefore,it is necessary to boost market supply continually and increase the public awareness rate of HPV vaccines.And it is advocated that the right age groups should be vaccinated as early as possible due to the favorable safety of the vaccines.

关 键 词：人乳头状瘤病毒疫苗 宫颈癌 接种状况 安全性 接种量 分析 

分 类 号：R186[医药卫生—流行病学] R711.74[医药卫生—公共卫生与预防医学]