派特灵治疗女性外阴尖锐湿疣临床效果观察  

Clinical effect of patelin in the treatment of female genital condyloma acuminatum

作　　者：徐海涛 赖沙 XU Hai-tao;LAI Sha(Department of Dermatology,Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 611731,China)

机构地区：[1]电子科技大学医学院附属妇女儿童医院(成都市妇女儿童中心医院)皮肤科,四川成都611731

出　　处：《临床军医杂志》2020年第6期659-660,664,共3页Clinical Journal of Medical Officers

摘　　要：目的观察派特灵治疗女性外阴尖锐湿疣的临床效果。方法将电子科技大学医学院附属妇女儿童医院自2017年2月至2019年2月收治的65例经电灼或二氧化碳激光治疗3次及以上仍复发的女性外阴尖锐湿疣患者纳入A组,将同期收治的65例无治疗史的女性外阴尖锐湿疣患者纳入B组。两组均接受外敷派特灵治疗:派特灵连续应用3 d,休息4 d,以7 d为1个疗程。比较两组患者治疗3个月的临床治愈率、疣体平均脱落时间、随访6个月的复发率,以及不良反应发生率。结果治疗3个月后,A组、B组治愈率分别为95.4%(62/65)、100.0%(65/65),差异无统计学意义(P>0.05)。B组疣体平均脱落时间为(13.86±3.06)d,短于A组的(22.45±4.17)d,差异有统计学意义(P<0.05)。随访6个月,A组、B组均无复发,复发率均为0,差异无统计学意义(P>0.05)。治疗期间,A组出现轻微红肿疼痛4例、轻微瘙痒6例,不良反应发生率为15.4%(10/65);B组出现轻微红肿疼痛3例、轻微瘙痒5例,不良反应发生率为12.3%(8/65)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。不良反应经对症处理后均缓解。结论派特灵治疗女性外阴尖锐湿疣安全、有效;经多次电灼或激光治疗仍复发的患者外敷派特灵也能获得满意的临床效果。Objective To observe the clinical effect of petelin in the treatment of female genital condyloma acuminatum.Methods Sixty-five female patients with genital condyloma acuminatum who had been treated by electric cauterization or carbon dioxide laser for three or more times from February 2017 to February 2019 were included in Group A,and sixty-five female patients with genital condyloma acuminatum who had not been treated in the same period were included in Group B.Both groups of patients received external application of partrim:continuous application of partrim for 3 days,rest for 4 days,and a course of treatment for 7 days.The clinical cure rate,average time of condyloma acuminatum shedding,recurrence rate and incidence of adverse reactions were compared between the two groups after 3 months of treatment.Results After 3 months of treatment,the cure rates of Group A and group B were 95.4%(62/65)and 100.0%(65/65),respectively,with no statistically significant difference(P>0.05).The average shedding time of condyloma acuminatum in Group B was(13.86±3.06)days,which was shorter than that in Group A(22.45±4.17)days,and the difference was statistically significant(P<0.05).After 6 months of follow-up,there was no recurrence in Group A and Group B,and the recurrence rate was 0 in both groups,with no statistically significant difference(P>0.05).During the treatment,there were 4 cases of mild redness,swelling and pain,and 6 cases of mild itching in Group A,and the incidence of adverse reactions was 15.4%(10/65).In Group B,there were 3 cases of mild redness,swelling and pain and 5 cases of mild itching,and the incidence of adverse reactions was 12.3%(8/65).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).The adverse reactions were alleviated after symptomatic treatment.Conclusion The treatment of female genital condyloma acuminatum is safe and effective;patients who still have a recurrence after repeated electrocautery or laser therapy can also obtain satisfactory clin

关 键 词：派特灵 女性 外阴 尖锐湿疣 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]