组蛋白修饰影响细胞辐射敏感性的研究进展  

Influence of histone modification on cell radiosensitivity

作　　者：周羽川 邵春林[1] Zhou Yuchuan;Shao Chunlin(Institution of Radiation Medicine,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学放射医学研究所,上海200032

出　　处：《中华放射医学与防护杂志》2020年第7期559-563,共5页Chinese Journal of Radiological Medicine and Protection

基　　金：国家重点研发计划(2017YFC0108604);国家自然科学基金(31770910,31570850)。

摘　　要：组蛋白修饰在细胞DNA损伤修复过程发挥重要作用。近年来多项研究表明,组蛋白修饰可以在参与招募DNA损伤修复因子、创建染色质开放结构和建立组蛋白抑制性标记等方面影响细胞对辐射的应答。同时,调控组蛋白修饰方式可以影响DNA损伤修复的过程,进而影响辐射敏感性。本文就组蛋白修饰影响DNA损伤修复过程与辐射敏感性的机制进行综述。Histone modification plays an important role in the process of cellular DNA damage repair.In recent years,a great number of studies have shown that histone modification affectsradiation responses including recruitment of DNA damage repair factors,creation of chromatin open structures and establishment of repressive histone marks.Regulation of histone modification may influence the process of DNA damage repair and thus affect radiation sensitivity.In this paper,the effects of histone modification on DNA damage repair,cellular radiosensitivity and the underlying mechanisms are reviewed.

关 键 词：组蛋白修饰 DNA损伤修复 辐射敏感性 

分 类 号：R818.02[医药卫生—放射医学]