儿童急性呼吸道感染的尿白三烯E4水平及影响因素  

Urine leukotriene E4 levels and influencing factors in children with acute respiratory infection

作　　者：陈广道 何伟健[2] 刘运可 庞焕香 李增清[1] Chen Guangdao;He Weijian;Liu Yunke;Pang Huanxiang;Li Zengqing(Department of Pediatrics,Guangdong Women and Children Hospital,Guangzhou 511442,China;Department of Health,Guangdong Women and Children Hospital,Guangzhou 511442,China)

机构地区：[1]广东省妇幼保健院儿童呼吸科,广州511442 [2]广东省妇幼保健院保健部,广州511442

出　　处：《中华临床医师杂志（电子版）》2020年第8期608-612,共5页Chinese Journal of Clinicians(Electronic Edition)

基　　金：广州市医药卫生科技项目(20131A011191)。

摘　　要：目的探讨半胱氨酰白三烯(CysLTs)在儿童急性呼吸道感染发病中的作用。方法选择2014年6月至2017年5月在广东省妇幼保健院接受治疗的急性呼吸道感染患儿63例和同期接受体检的健康儿童30名为研究对象,检测急性呼吸道感染和健康儿童的尿白三烯E4(LTE4)水平,并分别比较不同年龄、病情、病原体和有无过敏史的急性呼吸道感染患儿的尿LTE4水平的差异。结果急性呼吸道感染患儿尿LTE4水平显著高于健康儿童(t=20.400,P<0.001)。0~3岁组的尿LTE4水平显著高于4~6岁组及7~14岁组患儿(P均<0.05),且尿LTE4水平与年龄呈显著负相关(r=-0.487,P<0.001)。支气管肺炎患儿的尿LTE4水平显著高于急性支气管炎和上呼吸道感染患儿(P均<0.05)。肺炎支原体感染和病毒性感染患儿的尿LTE4水平显著高于细菌感染患儿(P均<0.05)。合并过敏史的患儿LTE4水平明显高于无过敏史的患儿(P<0.05)。结论CysLTs参与了儿童急性呼吸道感染的发病过程,尿LTE4水平与发病年龄、病情严重度、病原体和过敏史有关。Objective To investigate the role of leukotrienes in the pathogenesis of acute respiratory infection in children.Methods From June 2014 to May 2017,63 children with acute respiratory at Guangdong Women and Children Hospital and 30 healthy children who received physical examination at the same time were selected as the subjects,urinary leukotriene E4(LTE4)levels of children with acute respiratory infection and healthy cases were tested.Moreover,urinary LTE4 levels in children with acute respiratory infection were compared by sex,age,severity,pathogen,and allergic state.Results Urinary LTE4 level was significantly higher in children with acute respiratory infection than those of in healthy cases(t=20.400,P<0.001).Urinary LTE4 level in the 0-3 years old subgroup was significantly higher than those in the 4-6 and 7-14 years old subgroups(P<0.05),and urinary LTE4 levels were significantly negatively related to age(r=-0.487,P<0.001).Urinary LTE4 level of the bronchopneumonia subgroup was significantly higher than those of the acute bronchitis and acute upper respiratory infection subgroups(P<0.05).Urinary LTE4 levels of the mycoplasma pneumoniae and virus subgroups were significantly higher than that of the bacterial infection subgroup(P<0.05).The level of urinary LTE4 was significantly higher in children with allergic diseases than in those without(P<0.05).Conclusion Leukotrienes may be involved in the pathogenesis of acute respiratory infection,and urinary LTE4 levels are related to age,severity,pathogen,and allergic state of children.

关 键 词：急性呼吸道感染 儿童 白三烯E4 影响因素 

分 类 号：R725.6[医药卫生—儿科]