黄芪口服液中8种重金属元素含量的测定  

Determination of 8 Heavy Metals in Astragalus Oral Liquid

作　　者：刘晓艳 王晓雁 裴若会 LIU Xiaoyan;WANG Xiaoyan;PEI Ruohui(Shaanxi Institute of Geology and Mineral Resources Experiment Co.,Ltd.,Xi’an,Shaanxi 710054,China)

机构地区：[1]陕西省地质矿产实验研究所有限公司,西安710054

出　　处：《中国无机分析化学》2020年第4期32-35,共4页Chinese Journal of Inorganic Analytical Chemistry

摘　　要：在2015年版《中国药典》的基础上,采用原子荧光光谱法和电感耦合等离子体质谱法对黄芪口服液中的铅、砷、镉、汞、铜、锌、镍和铬进行测定,并对所用试剂、器皿,赶酸时间,内标的种类和加入方式进行了优化。结果表明,在样品处理前对器皿采用硝酸(30%)处理,赶酸时间在1.5 h以上,以手动方式加入单内标103Rh溶液,可以得到较准确、稳定的测定结果,8种元素测定的相对标准偏差(RSD)均小于4%,Hg、As、Cu、Pb、Zn、Cd、Ni、Cr的检出限分别为0.089、0.21、0.45、0.15、0.45、0.025、0.35和0.39μg/L,8种元素的加标回收率在92.0%~114%。方法对于黄芪口服液中痕量元素的检测,结果稳定,过程简单,引入污染小。In this paper,on the basis of the 2015 edition of Chinese pharmacopoeia,lead,arsenic,cadmium,mercury,copper,zinc,nickel and chromium in the astragalus oral liquid were determined by using atomic fluorescence spectrometry and inductively coupled plasma mass spectrometry,and the reagents,vessel,cast time,internal standards and adding method were optimized.Results showed that before the sample processing,the vessels was treated with nitric acid(30%),the acid time was more than 1.5 h,joined single internal standard manually,could get more accurate and stable determination results,RSD were less than 4%for the determination of 8 kinds of element,Hg,As,Cu,Pb,Zn,Cd,Ni and Cr of detection limit were 0.089,0.21,0.45,0.15,0.45,0.025,0.35 and 0.39μg/L,the recoveries of 8 elements were between 92.0%and 114%.This method can detect trace elements with stable results,simple process and less possibility of introducing blank.

关 键 词：黄芪口服液 重金属 电感耦合等离子体质谱法 

分 类 号：O657[理学—分析化学] TH744[理学—化学]