扎来普隆对利多卡因致小鼠惊厥作用的影响  

The influence of zaleplon on lidocaine-induced convulsion in mice

作　　者：陆培鑫 高震南 姜瑾颖 高敏 韩婷 陆雯斯 唐凌 王倩 王丹 LU Peixin;GAO Zhennan;JIANG Jinying;GAO Min;HAN Ting;LU Wensi;TANG Ling;WANG Qian;WANG Dan(Grade 2015,School of Anesthesiology,Xuzhou Medical University,Xuzhou,Jiangsu 221004,China;Department of Anesthetic Pharmacology,Xuzhou Medical University)

机构地区：[1]徐州医科大学麻醉学院,江苏徐州221004 [2]徐州医科大学麻醉药理学教研室

出　　处：《徐州医科大学学报》2020年第6期455-457,共3页Journal of Xuzhou Medical University

基　　金：江苏高校品牌专业建设工程(PPZY2015A066)。

摘　　要：目的观察不同剂量扎来普隆对利多卡因致小鼠惊厥作用的影响。方法将昆明种小鼠随机分为4组(n=10):生理盐水(NS)组及扎来普隆2 mg•kg^-1、4 mg•kg^-1、8 mg•kg^-1(Z2、Z4、Z8)组。以生理盐水或不同剂量的扎来普隆给小鼠灌胃,10 min后,各组腹腔注射利多卡因70 mg•kg^-1,观察小鼠的惊厥只数、惊厥率、惊厥潜伏期及惊厥级数。结果与NS组相比,Z8组小鼠惊厥率明显下降(P<0.01),Z2、Z4、Z8组小鼠惊厥潜伏期延长(P<0.05或P<0.01);扎来普隆使利多卡因致小鼠惊厥的级数降低(P<0.01)。结论扎来普隆能部分拮抗利多卡因的致小鼠惊厥作用。Objective To observe the influence of zaleplon on lidocaine-induced convulsion in mice.Methods The Kunming mice were randomly divided into four groups(n=10 each):normal saline(NS)group,zaleplon 2 mg·kg^-1,4 mg·kg^-1 and 8 mg·kg^-1(Z2,Z4,Z8)groups.Each group received intraperitoneal lidocaine 70 mg·kg^-1 10 min after NS or different doses of zaleplon had been administered by gavage.The number of convulsive mice,incidence of convulsion,convulsion latency and convulsion level were observed.Results Compared with NS group,the incidence of convulsion declined remarkably in Z8 group(P<0.01);the convulsion latency extended in Z2,Z4,Z8 groups(P<0.05,<0.01,and<0.01).Zaleplon could reduce the convulsion level induced by lidocaine in mice(P<0.01).Conclusions Zaleplon can partially antagonize lidocaine-induced convulsion in mice.

关 键 词：扎来普隆 利多卡因 惊厥 小鼠 

分 类 号：R971.2[医药卫生—药品]