徐州市60例COVID-19的流行特点和临床表现  

Epidemiological characteristics and clinical manifestation of COVID-19:60 cases in Xuzhou

作　　者：席向宇 王为民[1] 潘永[1] 王春颖[1] 刘慧梅[1] 张瑞梅[1] 闫家微 白鹄 XI Xiangyu;WANG Weimin;PAN Yong;WANG Chunying;LIU Huimei;ZHANG Ruimei;YAN Jiawei;BAI Hu(Xuzhou Infectious Diseases Hospital,Xuzhou,Jiangsu 221004,China)

机构地区：[1]徐州市传染病医院,江苏徐州221004

出　　处：《徐州医科大学学报》2020年第6期462-465,共4页Journal of Xuzhou Medical University

摘　　要：目的了解徐州地区2019冠状病毒病(COVID-19)的流行情况和临床特征,为疾病的预防控制提供基础,并为以后的机制研究提供线索。方法从住院电子病历中获取本院核酸检测阳性的60例COVID-19感染者的资料,描述病例的人口学特点、流行情况、临床症状、实验室检查指标,胸部CT表现和治疗情况。结果60例COVID-19病例的中位平均年龄是39.5岁,主要集中于15~49岁。男女比例为22/38。83.3%的病例是普通型,71.7%的患者是在本地接触COVID-19病例感染,17例(28.3%)为疫区接触感染。患者的主要症状有发热(63.3%)、胸闷(48.3%)、咳痰(41.7%)、咳嗽(31.7%)等;咯血(1.7%)和肌痛/关节痛(5.0%)比较少见;有20%的患者伴有高血压等其他疾病。实验室检查异常的指标有白细胞(28.3%)、中性粒细胞(28.3%)和淋巴细胞减少(46.7%),C反应蛋白(40.0%)和乳酸脱氢酶升高(33.3%),低白蛋白血症(48.3%)、低钾(38.3%)和凝血酶原时间延长(41.7%)。抗体IgM和IgG的阳性率分别为71.7%和53.3%。CT检查中最常见的异常为磨玻璃结节(86.7%)和间质病变(40%),双侧病变多于单侧。经过系统化治疗后,所有的患者都痊愈并出院。结论COVID-19普遍易感,徐州市传染病医院收治的患者大部分集中在青壮年,发热为最常见的症状。入院时淋巴细胞减少、C反应蛋白升高为常见的实验室检查异常,而CT检查最常见的病变为磨玻璃结节。Objective To understand the prevalence and clinical characteristics of coronavirus disease 2019(COVID-19)in Xuzhou,and provide evidence for the prevention and control of the disease and offer clues for further mechanism studies.Methods Clinical data were collected from 60 COVID-19 patients positive in nucleic acid test in Xuzhou Infectious Diseases Hospital.The information on demographic,epidemiological and clinical characteristics,laboratory test indicators,chest CT manifestation,and treatment was analyzed.Results For these 60 COVID-19 patients,the median age was 39.5 years,ranging from 15 to 49 years old,with a male/female sex ratio of 22/38.Moreover,83.3%patients were common cases,while 71.7%patients were infected due to contact with local COVID-19 patients.Meanwhile,17 patients(28.3%)were infected due to contact with COVID-19 patients in epidemic areas.The main symptoms included fever(63.3%),chest distress(48.3%),expectoration(41.7%)and cough(31.7%),while hemoptysis(1.7%)and myalgia or arthralgia(5.0%)were uncommon,and 20%patients suffered from other diseases such as hypertension.According to laboratory examination,46.7%patients had lymphocytopenia,28.3%had leukopenia and neutropenia;40.0%had elevated C-reactive protein(CRP)and 33.3%had elevated lactate dehydrogenase;48.3%had hypoalbuminemia,38.3%had low potassium,and 41.7%had extended prothrombin time.The positive rate of IgM and IgG was 71.7%and 53.3%,respectively.According to CT examination,the most common problems were ground-glass opacity(86.7%)and interstitial abnormalities(40%),with more bilateral loci.All patients recovered and were discharged after systematic treatment.Conclusions All patients are generally susceptible to COVID-19.Most of COVID-19 patients in our hospital are young adults,with most common symptom of fever.On admission,lymphocytopenia and elevated CRP are commonly seen for laboratory examination,while ground-glass opacity is the most common issue for CT scanning.

关 键 词：2019冠状病毒病 流行特点 临床特征 

分 类 号：R512.99[医药卫生—内科学]