前列地尔联合硫辛酸治疗老年糖尿病周围神经病变的效果  

Clinical effect of alprostadil combined with lipoic acid on diabetic peripheral neuropathy in the elderly

作　　者：李泉慧 李维欣[2] 贾晨晨 Li Quanhui;Li Weixin;Jia Chenchen(Department of Geriatric Endocrinology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Ophthalmology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Health Management,Henan People's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州大学第一附属医院老年内分泌病区,郑州450000 [2]郑州大学第一附属医院眼科,郑州450000 [3]河南省人民医院健康管理科,郑州450000

出　　处：《临床医学》2020年第6期78-80,共3页Clinical Medicine

摘　　要：目的研究前列地尔与硫辛酸联合治疗老年糖尿病周围神经病变的临床效果。方法选取2018年2月至2019年2月郑州大学第一附属医院收治的60例老年糖尿病周围神经病变患者为研究对象,根据随机数字表法分为研究组和对照组,每组30例。对照组患者进行硫辛酸治疗,研究组患者给予前列地尔与硫辛酸联合治疗。对比分析研究组与对照组患者的临床治疗效果及神经传导速度等临床指标。结果研究组的治疗有效率高于对照组,差异有统计学意义(P<0.05)。研究组患者的正中运动神经传导速度(MNCV)、正中感觉神经传导速度(SNCV)、腓浅神经MNCV、腓浅神经SNCV均显著高于对照组,差异有统计学意义(P<0.05)。研究组患者症状改善时间为(13.12±1.02)d,对照组为(17.32±1.44)d,差异有统计学意义(P<0.05)。结论应用前列地尔、硫辛酸联合治疗老年糖尿病周围神经病变临床效果理想,可显著改善患者相关临床症状,提高患者神经传导速度,帮助患者尽快恢复健康。Objective To study the clinical effect of alprostadil and lipoic acid on diabetic peripheral neuropathy in the elderly.Methods From February 2018 to February 2019,60 elderly patients with diabetic peripheral neuropathy in the First Affiliated Hospital of Zhengzhou University were selected as the research objects.The patients were randomly divided into control group and study group,with 30 cases in each group.The patients in the control group were treated with lipoic acid,and the patients in the study group were treated with alprostadil and lipoic acid.The clinical therapeutic effect and nerve conduction velocity were compared between the experimental group and the control group.Results The effective rate of treatment in the study group was higher than that in the control group(P<0.05).The median motor nerve conduction velocity(MNCV),median sensory nerve conduction velocity(SNCV),superficial peroneal nerve MNCV and superficial peroneal nerve SNCV in the study group were significantly higher than those in the control group,the differences were significant(P<0.05).The improvement time of symptoms in the study group was(13.12±1.02)days,and that in the control group was(17.32±1.44)days,there was significant difference(P<0.05).Conclusions The clinical effect of alprostadil and lipoic acid on diabetic peripheral neuropathy in the elderly is ideal,which can significantly improve the related clinical symptoms,improve the nerve conduction velocity of the patients,help the patients recover health as soon as possible.

关 键 词：前列地尔 硫辛酸 老年糖尿病 周围神经病变 临床效果 

分 类 号：R587.2[医药卫生—内分泌]