脂肪乳剂在急性脂溶性药物中毒治疗中的应用  

Application of fat emulsion in acute liposoluble drug poisoning

作　　者：孙雯雯 胡亚兰[1] 张绵[1] 朱占占 郑鸿翔[1] Sun Wenwen;Hu Yalan;Zhang Mian;Zhu Zhanzhan;Zheng Hongxiang(Comprehensive Intensive Care Unit,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Cardiology,the Seventh People’s Hospital of Zhengzhou,Zhengzhou 450000,China)

机构地区：[1]河南省郑州市第七人民医院综合重症监护室,450000 [2]河南省郑州市第七人民医院心内科,450000

出　　处：《临床医学》2020年第6期83-85,共3页Clinical Medicine

摘　　要：目的探讨脂肪乳剂在急性脂溶性药物中毒中的应用效果。方法回顾性分析郑州市第七人民医院2018年2月至2019年2月收治的72例急性脂溶性药物中毒患者的临床资料,按照随机数字表法分为观察组和对照组,每组36例。对照组患者使用相应的解毒药物治疗,观察组患者在对照组的基础上联合使用脂肪乳剂治疗。比较两组患者治疗前后心功能指标及血气指标的变化情况。结果治疗后,观察组患者血浆B型利肽钠(BNP)、左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)值均低于对照组患者,左心射血分数(LVEF)值[(58.88±7.91)%]比对照组患者[(53.49±7.77)%]高,差异有统计学意义(P<0.05);且观察组患者动脉血氧饱和度(SaO2)、氧分压(PaO2)及酸碱度(pH)值均高于对照组患者,二氧化碳分压(PaCO2)值比对照组患者低,差异有统计学意义(P<0.05)。结论采用脂肪乳剂对急性脂溶性药物中毒患者进行治疗,可有效改善患者的血气指标,促进其心功能恢复,疗效显著。Objective To investigate the clinical application of fat emulsion in acute liposoluble drug poisoning.Methods The clinical data of 72 patients with acute liposoluble drug poisoning admitted to the Seventh People’s Hospital of Zhengzhou from February 2018 to February 2019 were retrospectively analyzed.They were divided into observation group and control group according to random number table method,with 36 cases in each group.The patients in the control group were treated with antidote drugs,while the patients in the observation group were treated with fat emulsion on the basis of the control group.The changes of cardiac function and blood gas were compared between the two groups before and after treatment.Results After treatment,the plasma B-type natriuretic peptide(BNP),left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)in the observation group were lower than those in the control group,and left ventricular ejection fraction(LVEF)[(58.88±7.91)%]was higher than those in the control group[(53.49±7.77)%],the differences were significant(P<0.05).The values of oxygen saturation(SaO2),partial pressure of oxygen(PaO2)and acidity-alkalinity(pH)were higher than those of the control group,while the values of partial pressure of carbon dioxide(PaCO2)were lower than those of the control group,with significant difference(P<0.05).Conclusions Fat emulsion can effectively improve the blood gas index and promote the recovery of cardiac function in patients with acute liposoluble drug poisoning.

关 键 词：急性脂溶性药物中毒 脂肪乳剂 心功能 血气指标 

分 类 号：R595.4[医药卫生—内科学]