去氨加压素联合奥昔布宁治疗儿童原发性夜遗尿症的疗效  

Effect of combined application of desmopressin and oxybutynin on children with primary nocturnal enuresis

作　　者：马玉花[1] Ma Yuhua(Department of Pediatrics,Foshan Maternal and Child Health Hospital,Foshan 528000,China)

机构地区：[1]广东省佛山市妇幼保健院儿科,528000

出　　处：《临床医学》2020年第6期88-90,共3页Clinical Medicine

摘　　要：目的探讨去氨加压素联合奥昔布宁治疗儿童原发性夜遗尿症(PNE)的疗效。方法选取2017年11月至2019年10月在佛山市妇幼保健院治疗的120例PNE患儿,采用随机数字表法将其分为两组,每组60例。对照组采取醋酸去氨加压素治疗;观察组在此基础上,联合应用奥昔布宁。比较两组的总有效率、复发率及不良反应发生率。结果观察组患儿的总有效率为96.67%(58/60),对照组为76.67%(46/60),差异有统计学意义(P<0.05);随访期间,观察组复发率为1.67%(1/60),对照组为11.67%(7/60),差异有统计学意义(P<0.05);治疗期间,观察组患儿不良反应率为6.67%(4/60),对照组为3.33%(2/60),差异未见统计学意义(P>0.05)。结论对PNE患儿联合使用去氨加压素和奥昔布宁治疗,可提高临床疗效,降低复发率,且安全性良好。Objective To investigate the effect of combined application of desmopressin and oxybutynin on children with primary nocturnal enuresis.Methods From November 2017 to October 2019,120 children with PNE treated in Foshan Maternal and Child Health Hospital were selected and divided into two groups,with 60 cases in each group.The patients in the control group were treated with desmopressin acetate,and the patients in the observation group were combined with oxybutynin.The total effective rate,recurrence rate and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 96.67%(58/60),that of the control group was 76.67%(46/60),the difference was significant(P<0.05);during the follow-up,the recurrence rate of the observation group was 1.67%(1/60),that of the control group was 11.67%(7/60),the difference was significant(P<0.05);during the treatment,the adverse reaction rate of the observation group was 6.67%(4/60),that of the control group was 3.33%(2/60),the difference was not significant(P>0.05).Conclusions Combined use of desmopressin and oxybutynin in children with PNE can improve the clinical efficacy,and reduce the recurrence rate.

关 键 词：夜遗尿症 奥昔布宁 去氨加压素 

分 类 号：R726.9[医药卫生—儿科]