依地酸钙钠治疗系统性硬化症的效果  

Effect of calcium disodium edetate on systemic sclerosis

作　　者：王文晶 邓昊[1] 李捷[2] 张朝阳 黄玉萍[2] 裴丁楠 Wang Wenjing;Deng Hao;Li Jie;Zhang Chaoyang;Huang Yuping;Pei Dingnan(Department of Rheumatology and Immunology,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China;Immune Laboratory,the Second Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第二附属医院风湿免疫科,河南洛阳471000 [2]河南科技大学第二附属医院免疫实验室,河南洛阳471000

出　　处：《临床医学》2020年第5期109-111,共3页Clinical Medicine

基　　金：2019年度洛阳市科学技术局科研项目(1950001A)。

摘　　要：目的探讨依地酸钙钠在系统性硬化症治疗中的应用效果。方法选取2016年7月至2018年12月河南科技大学第二附属医院收治的58例系统性硬化症患者。根据随机数字表法分为研究组与对照组,每组29例。对照组予以常规用药方案,研究组在常规治疗基础上加用依地酸钙钠,记录两组的临床疗效。结果治疗前,两组改良Rodnan评分结果比较差异未见统计学意义(P>0.05);治疗后,两组改良Rodnan评分结果均下降,差异有统计学意义(P<0.05);研究组治疗后改良Rodnan评分较之前变化幅度更优,差异有统计学意义(P<0.05)。结论依地酸钙钠能够显著提高系统性硬化症患者的临床疗效。Objective To investigate the effect of calcium disodium edetate on systemic sclerosis.Methods From July 2016 to December 2018,58 patients with systemic sclerosis were selected from the Second Affiliated Hospital of Henan University of Science and Technology.According to the random number table,the patients were divided into the study group and the control group,with 29 cases in each group.The control group was given the routine treatment plan,and the study group was added with calcium disodium edetate on the basis of routine treatment,and the clinical efficacy of the two groups was recorded.Results Before the treatment,there was no significant difference in the modified Rodnan score between the two groups(P>0.05).After treatment,the modified Rodnan score of the two groups decreased,the differences were significant(P<0.05).After treatment,the modified Rodnan score of the study group changed more significantly than before(P<0.05).Conclusions Calcium disodium edetate can significantly improve the clinical efficacy of patients with systemic sclerosis.

关 键 词：系统性硬化症 依地酸钙钠 效果 

分 类 号：R593.2[医药卫生—内科学]